DegronMD - Q8TBE0(BAHD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M318T	TCGA-06-0122	GBM	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6312
p.M318T	DO12514	GBM	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6312
p.Q340H	TCGA-2G-AAH3	TGCT	TCGA	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1111
p.R172W	TCGA-2W-A8YY	CESC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7523
p.R172W	DO223732	CESC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7523
p.R5W	TCGA-A5-A0G2	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7523
p.R5W	TCGA-EE-A2MR	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7523
p.R5W	DO37819	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7523
p.R5W	DO41235	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7523
p.S353L	TCGA-A5-A1OF	UCEC	TCGA	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7667
p.S353L	TCGA-AP-A0LM	UCEC	TCGA	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7667
p.S353L	DO43306	UCEC	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7667
p.S353L	DO42568	UCEC	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7667
p.S14L	TCGA-AP-A056	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	TCGA-E6-A1LX	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	DO222868	MELA	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	DO41020	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	DO43971	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	SIDM00193	Colorectal Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	ACH-000991	Colon/Colorectal Cancer	CCLE	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.S14L	SNU-81	large intestine	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.P187S	TCGA-AP-A059	UCEC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0556
p.P187S	DO41361	UCEC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0556
p.P315S	TCGA-AP-A0LM	UCEC	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.5641
p.P315S	DO43306	UCEC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.5641
p.S13C	TCGA-AX-A3G9	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.643
p.S13C	DO41241	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.643
p.R19L	TCGA-B5-A11U	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.1667
p.R19L	DO40804	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.1667
p.S664I	TCGA-B5-A3FA	UCEC	TCGA	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.2222
p.S664I	DO52402	UCEC	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.2222
p.M357L	TCGA-B7-5816	STAD	TCGA	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.M357L	DO38599	STAD	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.G163D	TCGA-BH-A0HF	BRCA	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1667
p.G163D	DO1749	BRCA	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1667
p.R311H	TCGA-D1-A167	UCEC	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8244
p.R311H	DO40978	UCEC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.8244
p.R170W	TCGA-D7-8570	STAD	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.8634
p.R170W	DO48040	STAD	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.8634
p.P354L	TCGA-DC-6682	READ	TCGA	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.3056
p.P354L	DO37162	READ	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.3056
p.P354L	SIDM01619	Endometrial Carcinoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.3056
p.P354L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.3056
p.P22S	TCGA-EE-A29E	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.P22S	DO37831	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.P22L	TCGA-EE-A29E	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.P22L	DO37831	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.S184Y	TCGA-EO-A22R	UCEC	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation blocking phosphorylation signal	0.5833
p.S184Y	DO42713	UCEC	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation blocking phosphorylation signal	0.5833
p.S8F	TCGA-FR-A726	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7982
p.S8F	DO48665	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7982
p.A651V	TCGA-FR-A7U9	SKCM	TCGA	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.2222
p.A651V	DO48546	SKCM	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.2222
p.R533H	TCGA-G4-6586	COAD	TCGA	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.1667
p.R533H	DO9698	COAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.1667
p.R533H	ACH-000700	Lung Cancer	CCLE	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.1667
p.A160D	TCGA-GL-A4EM	KIRP	TCGA	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0833
p.A160D	DO44520	KIRP	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0833
p.E657K	TCGA-XF-A9T5	BLCA	TCGA	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation altering degron motif	0.7022
p.E657K	DO51925	BLCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation altering degron motif	0.7022
p.S650Y	TCGA-XK-AAIW	PRAD	TCGA	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.1944
p.S650Y	DO51407	PRAD	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.1944
p.S658L	DO1076	BRCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation altering degron motif	0.7667
p.P350T	DO230326	COCA	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7031
p.P517S	DO234462	ESAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.2222
p.A323S	DO228948	LICA	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.1944
p.S13I	DO229015	LICA	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.623
p.P354S	DO229039	LICA	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.3056
p.V511L	DO229037	LICA	ICGC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.0556
p.E327A	DO23428	LINC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation rewiring degron network	0.0833
p.H343R	DO45087	LINC	ICGC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1944
p.H343R	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1944
p.H343R	NCI-H1563	lung	COSMIC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1944
p.M662K	DO33712	PACA	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation rewiring degron network	0.2778
p.S306N	DO228138	PBCA	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation blocking phosphorylation signal	0.6667
p.P536S	DO47929	STAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.0833
p.E657Q	DO229272	THCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	655:660	Mutation altering degron motif	0.6744
p.K168N	DO229221	THCA	ICGC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.3056
p.P348S	SIDM00422	Hodgkin's Lymphoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6752
p.P348S	ACH-001203	Lymphoma	CCLE	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6752
p.P348S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PTPQLS	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6752
p.P528S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.3056
p.P528S	ACH-002272	Lymphoma	CCLE	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.3056
p.P528S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation rewiring degron network	0.3056
p.R19H	SIDM00377	Other Sarcomas	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.1667
p.R19H	SKN	soft tissue	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.1667
p.R5Q	SIDM00969	Ovarian Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6218
p.R5Q	SIDM00032	Bladder Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6218
p.R5Q	SIDM00807	Bladder Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6218
p.R5Q	SIDM00793	Burkitt's Lymphoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6218
p.R5Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6218
p.M11L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.5999
p.M11L	H513	pleura	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.5999
p.D175H	SIDM00003	Melanoma	GDSC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6577
p.D175H	ACH-000884	Skin Cancer	CCLE	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6577
p.D175H	ACH-002159	Skin Cancer	CCLE	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6577
p.D175H	M14	skin	COSMIC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6577
p.R170Q	SIDM00887	Other Solid Cancers	GDSC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7329
p.R170Q	Daoy	central nervous system	COSMIC	KRPRLGDLG	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7329
p.T523A	SIDM00900	Non-Cancerous	GDSC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation altering degron motif	0.7139
p.L316P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6471
p.L316P	ACH-000937	Leukemia	CCLE	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6471
p.L316P	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRPHLPLLM	DEG_APCC_DBOX_1	310:318	Mutation altering degron motif	0.6471
p.P527S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LQTPTSE	DEG_SCF_FBW7_2	521:527	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAHD1

UniProt ID: Q8TBE0

Entrez ID: 22893

Protein name: Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BAHD1 in