DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9878

ASA_SCORE: 111.2889

COIL: 0.9189

CONS_SCORE: 0.3817

DSS_SCORE: 0.7865

HELIX: 0.0471

FCONS_SCORE: 1.1297

RIG_SCORE: 0.6945

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5W	TCGA-A5-A0G2	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.7523
p.R5W	TCGA-EE-A2MR	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.7523
p.R5W	DO37819	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.7523
p.R5W	DO41235	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.7523
p.S14L	TCGA-AP-A056	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	TCGA-E6-A1LX	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	DO222868	MELA	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	DO41020	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	DO43971	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	SIDM00193	Colorectal Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	ACH-000991	Colon/Colorectal Cancer	CCLE	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S14L	SNU-81	large_intestine	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	0.3056
p.S13C	TCGA-AX-A3G9	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.643
p.S13C	DO41241	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.643
p.R19L	TCGA-B5-A11U	UCEC	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.1667
p.R19L	DO40804	UCEC	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.1667
p.P22S	TCGA-EE-A29E	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.0833
p.P22S	DO37831	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.0833
p.P22L	TCGA-EE-A29E	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.0833
p.P22L	DO37831	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.0833
p.S8F	TCGA-FR-A726	SKCM	TCGA	RRKSLPMLS	DEG_APCC_DBOX_1	0.7982
p.S8F	DO48665	SKCM	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.7982
p.S13I	DO229015	LICA	ICGC	RRKSLPMLS	DEG_APCC_DBOX_1	0.623
p.R19H	SIDM00377	Other Sarcomas	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.1667
p.R19H	SKN	soft_tissue	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	0.1667
p.R5Q	SIDM00969	Ovarian Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.6218
p.R5Q	SIDM00032	Bladder Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.6218
p.R5Q	SIDM00807	Bladder Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.6218
p.R5Q	SIDM00793	Burkitt's Lymphoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.6218
p.R5Q	SIDM00760	Small Cell Lung Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.6218
p.M11L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RRKSLPMLS	DEG_APCC_DBOX_1	0.5999
p.M11L	H513	pleura	COSMIC	RRKSLPMLS	DEG_APCC_DBOX_1	0.5999

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKSLPMLS

Degron related mutations and impact score

Drug responses associated with BAHD1 mutations

All proteins holding degron of RRKSLPMLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_APCC_DBOX_1	5:13	RRKSLPMLS	APC,CDC20,FZR1	0.9878	More...