DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_APCC_DBOX_1

Location: 310:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5753

ASA_SCORE: 62.7556

COIL: 0.6027

CONS_SCORE: 0.3414

DSS_SCORE: 0.5738

HELIX: 0.2232

FCONS_SCORE: 1.0613

RIG_SCORE: 0.6908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M318T	TCGA-06-0122	GBM	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	0.6312
p.M318T	DO12514	GBM	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.6312
p.P315S	TCGA-AP-A0LM	UCEC	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	0.5641
p.P315S	DO43306	UCEC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.5641
p.R311H	TCGA-D1-A167	UCEC	TCGA	LRPHLPLLM	DEG_APCC_DBOX_1	0.8244
p.R311H	DO40978	UCEC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.8244
p.A323S	DO228948	LICA	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.1944
p.E327A	DO23428	LINC	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.0833
p.S306N	DO228138	PBCA	ICGC	LRPHLPLLM	DEG_APCC_DBOX_1	0.6667
p.L316P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRPHLPLLM	DEG_APCC_DBOX_1	0.6471
p.L316P	ACH-000937	Leukemia	CCLE	LRPHLPLLM	DEG_APCC_DBOX_1	0.6471
p.L316P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRPHLPLLM	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_APCC_DBOX_1	310:318	LRPHLPLLM	APC,CDC20,FZR1	0.5753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons