DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_Kelch_Keap1_1

Location: 655:660

E3 ligase: KEAP1

DEGRON score: 0.8376

ASA_SCORE: 76.2167

COIL: 0.8573

CONS_SCORE: 0.6078

DSS_SCORE: 0.1171

HELIX: 0.0517

FCONS_SCORE: 0.7555

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S664I	TCGA-B5-A3FA	UCEC	TCGA	NPESGE	DEG_Kelch_Keap1_1	0.2222
p.S664I	DO52402	UCEC	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.2222
p.A651V	TCGA-FR-A7U9	SKCM	TCGA	NPESGE	DEG_Kelch_Keap1_1	0.2222
p.A651V	DO48546	SKCM	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.2222
p.E657K	TCGA-XF-A9T5	BLCA	TCGA	NPESGE	DEG_Kelch_Keap1_1	0.7022
p.E657K	DO51925	BLCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.7022
p.S650Y	TCGA-XK-AAIW	PRAD	TCGA	NPESGE	DEG_Kelch_Keap1_1	0.1944
p.S650Y	DO51407	PRAD	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.1944
p.S658L	DO1076	BRCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.7667
p.M662K	DO33712	PACA	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.2778
p.E657Q	DO229272	THCA	ICGC	NPESGE	DEG_Kelch_Keap1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_Kelch_Keap1_1	655:660	NPESGE	KEAP1	0.8376	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons