DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_SCF_FBW7_1

Location: 348:353

E3 ligase: FBXW7

DEGRON score: 0.9677

ASA_SCORE: 73.1333

COIL: 0.9228

CONS_SCORE: 0.3471

DSS_SCORE: 0.7365

HELIX: 0.026

FCONS_SCORE: 0.961

RIG_SCORE: 0.6103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q340H	TCGA-2G-AAH3	TGCT	TCGA	PTPQLS	DEG_SCF_FBW7_1	0.1111
p.S353L	TCGA-A5-A1OF	UCEC	TCGA	PTPQLS	DEG_SCF_FBW7_1	0.7667
p.S353L	TCGA-AP-A0LM	UCEC	TCGA	PTPQLS	DEG_SCF_FBW7_1	0.7667
p.S353L	DO43306	UCEC	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.7667
p.S353L	DO42568	UCEC	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.7667
p.M357L	TCGA-B7-5816	STAD	TCGA	PTPQLS	DEG_SCF_FBW7_1	0.2222
p.M357L	DO38599	STAD	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.2222
p.P354L	TCGA-DC-6682	READ	TCGA	PTPQLS	DEG_SCF_FBW7_1	0.3056
p.P354L	DO37162	READ	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.3056
p.P354L	SIDM01619	Endometrial Carcinoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	0.3056
p.P354L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PTPQLS	DEG_SCF_FBW7_1	0.3056
p.P350T	DO230326	COCA	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.7031
p.P354S	DO229039	LICA	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.3056
p.H343R	DO45087	LINC	ICGC	PTPQLS	DEG_SCF_FBW7_1	0.1944
p.H343R	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	0.1944
p.H343R	NCI-H1563	lung	COSMIC	PTPQLS	DEG_SCF_FBW7_1	0.1944
p.P348S	SIDM00422	Hodgkin's Lymphoma	GDSC	PTPQLS	DEG_SCF_FBW7_1	0.6752
p.P348S	ACH-001203	Lymphoma	CCLE	PTPQLS	DEG_SCF_FBW7_1	0.6752
p.P348S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPQLS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_SCF_FBW7_1	348:353	PTPQLS	FBXW7	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons