DegronMD

Uniprot ID: Q8TBE0

Source protein: Bromo adjacent homology domain-containing 1 protein

Source gene: BAHD1

Class: DEG_SCF_FBW7_2

Location: 521:527

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 100.8

COIL: 0.9479

CONS_SCORE: 0.3895

DSS_SCORE: 0.6893

HELIX: 0.0271

FCONS_SCORE: 0.9414

RIG_SCORE: 0.6301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R533H	TCGA-G4-6586	COAD	TCGA	LQTPTSE	DEG_SCF_FBW7_2	0.1667
p.R533H	DO9698	COAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	0.1667
p.R533H	ACH-000700	Lung Cancer	CCLE	LQTPTSE	DEG_SCF_FBW7_2	0.1667
p.P517S	DO234462	ESAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	0.2222
p.V511L	DO229037	LICA	ICGC	LQTPTSE	DEG_SCF_FBW7_2	0.0556
p.P536S	DO47929	STAD	ICGC	LQTPTSE	DEG_SCF_FBW7_2	0.0833
p.P528S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQTPTSE	DEG_SCF_FBW7_2	0.3056
p.P528S	ACH-002272	Lymphoma	CCLE	LQTPTSE	DEG_SCF_FBW7_2	0.3056
p.P528S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPTSE	DEG_SCF_FBW7_2	0.3056
p.T523A	SIDM00900	Non-Cancerous	GDSC	LQTPTSE	DEG_SCF_FBW7_2	0.7139
p.P527S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPTSE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBE0	Bromo adjacent homology domain-containing 1 protein	DEG_SCF_FBW7_2	521:527	LQTPTSE	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons