DegronMD

Uniprot ID: Q76NI1

Source protein: Kinase non-catalytic C-lobe domain-containing protein 1

Source gene: KNDC1

Class: DEG_APCC_DBOX_1

Location: 989:997

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.988

ASA_SCORE: 98.9222

COIL: 0.8406

CONS_SCORE: 0.4483

DSS_SCORE: 0.8031

HELIX: 0.1328

FCONS_SCORE: 1.0296

RIG_SCORE: 0.5769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R984L	TCGA-77-8130	LUSC	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R984L	DO26566	LUSC	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.A1002V	TCGA-B7-A5TI	STAD	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.A1002V	DO222328	STAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R990G	TCGA-BL-A13J	BLCA	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.7568
p.R990G	DO536	BLCA	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.7568
p.R984H	TCGA-BR-8686	STAD	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R984H	DO48036	STAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R984S	TCGA-D3-A8GQ	SKCM	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R984S	DO51246	SKCM	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1944
p.R1005K	TCGA-FW-A3R5	SKCM	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.1111
p.R1005K	DO37406	SKCM	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1111
p.K998E	TCGA-VR-A8Q7	ESCA	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	0.3056
p.P991L	DO234350	ESAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	0.6471
p.P983L	SIDM00879	Breast Carcinoma	GDSC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1667
p.R995C	SIDM01619	Endometrial Carcinoma	GDSC	KRPSLHRLG	DEG_APCC_DBOX_1	0.719
p.R995C	ACH-000984	Endometrial/Uterine Cancer	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	0.719
p.K998Q	ACH-001991	Primary	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	0.3056
p.K989T	ACH-002693	Sarcoma	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	0.6195
p.A1005V	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	KRPSLHRLG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76NI1	Kinase non-catalytic C-lobe domain-containing protein 1	DEG_APCC_DBOX_1	989:997	KRPSLHRLG	APC,CDC20,FZR1	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons