DegronMD - Q76NI1(KNDC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R984L	TCGA-77-8130	LUSC	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.R984L	DO26566	LUSC	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.A1439T	TCGA-B5-A11F	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.1111
p.A1439T	DO43618	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.1111
p.R1432H	TCGA-B5-A1MV	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.3056
p.R1432H	DO43354	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.3056
p.A1002V	TCGA-B7-A5TI	STAD	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.A1002V	DO222328	STAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.Q1704H	TCGA-BA-A6DA	HNSC	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.0556
p.Q1704H	DO44448	HNSC	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.0556
p.R990G	TCGA-BL-A13J	BLCA	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.7568
p.R990G	DO536	BLCA	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.7568
p.Y1701C	TCGA-BR-4184	STAD	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation blocking phosphorylation signal	0.5833
p.Y1701C	DO38328	STAD	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation blocking phosphorylation signal	0.5833
p.R984H	TCGA-BR-8686	STAD	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.R984H	DO48036	STAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.S859I	TCGA-CR-7364	HNSC	TCGA	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.1944
p.S859I	DO15679	HNSC	ICGC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.1944
p.R984S	TCGA-D3-A8GQ	SKCM	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.R984S	DO51246	SKCM	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1944
p.H1683R	TCGA-D8-A1XK	BRCA	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.1944
p.H1683R	DO4749	BRCA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.1944
p.G1423E	TCGA-D9-A6EC	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.G1423E	DO50291	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.A1684V	TCGA-E1-5318	LGG	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2222
p.A1684V	DO22195	LGG	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2222
p.T1435I	TCGA-EB-A41A	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.2222
p.T1435I	DO37429	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.2222
p.P1441H	TCGA-ER-A193	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.0556
p.P1441H	DO47368	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.0556
p.H1683Y	TCGA-F7-A624	HNSC	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.1944
p.H1683Y	DO44440	HNSC	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.1944
p.Y1690C	TCGA-F7-A624	HNSC	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation altering degron motif	0.7087
p.Y1690C	DO44440	HNSC	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation altering degron motif	0.7087
p.P1441S	TCGA-FI-A2D5	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.0556
p.P1441S	DO41331	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.0556
p.R1005K	TCGA-FW-A3R5	SKCM	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1111
p.R1005K	DO37406	SKCM	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1111
p.P1696H	TCGA-GN-A26C	SKCM	TCGA	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2778
p.P1696H	DO37782	SKCM	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2778
p.K998E	TCGA-VR-A8Q7	ESCA	TCGA	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.3056
p.S1693R	DO224818	BRCA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation altering degron motif	0.6316
p.P991L	DO234350	ESAD	ICGC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.6471
p.L1698I	DO233266	GACA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2222
p.A1684T	DO233748	GACA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.2222
p.K1703N	DO228976	LICA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation substituting flanking lysine	0.1944
p.A1438S	DO229019	LICA	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.1389
p.S1693I	DO229019	LICA	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation altering degron motif	0.623
p.G848E	DO50970	LICA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation altering degron motif	0.6087
p.D856G	DO50966	LICA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.2778
p.G853E	DO222702	MELA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation altering degron motif	0.6087
p.S1680R	DO232919	PEME	ICGC	NPYTFSP	CBL_PTK	1688:1694	Mutation rewiring degron network	0.1111
p.K1430E	DO229211	THCA	ICGC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation altering degron motif	0.591
p.D857E	SIDM00672	Hepatocellular Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM00969	Ovarian Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM00525	Osteosarcoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.D857E	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.25
p.E1431K	SIDM00915	Small Cell Lung Carcinoma	GDSC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation altering degron motif	0.7022
p.E1431K	NCI-H378	lung	COSMIC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation altering degron motif	0.7022
p.Y1434C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.Y1434C	ACH-001669	Leukemia	CCLE	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.Y1434C	ACH-002238	Leukemia	CCLE	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.Y1434C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.25
p.P983L	SIDM00879	Breast Carcinoma	GDSC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1667
p.R1432C	SIDM00668	Non-Cancerous	GDSC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.3056
p.R1432C	ACH-002245	Lymphoma	CCLE	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.3056
p.R1432C	Hs-445	haematopoietic and lymphoid tissue	COSMIC	LPPHKE	LIG_APCC_ABBA_1	1426:1431	Mutation rewiring degron network	0.3056
p.G848R	SIDM00980	Gastric Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation altering degron motif	0.6457
p.R995C	SIDM01619	Endometrial Carcinoma	GDSC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.719
p.R995C	ACH-000984	Endometrial/Uterine Cancer	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.719
p.E843A	ACH-000515	Lung Cancer	CCLE	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.2222
p.R839H	ACH-001536	Bile Duct Cancer	CCLE	PGATPAGE	DEG_SCF_FBW7_2	847:854	Mutation rewiring degron network	0.1111
p.K998Q	ACH-001991	Primary	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.3056
p.K989T	ACH-002693	Sarcoma	CCLE	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation altering degron motif	0.6195
p.A1005V	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	KRPSLHRLG	DEG_APCC_DBOX_1	989:997	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KNDC1

UniProt ID: Q76NI1

Entrez ID: 85442

Protein name: Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KNDC1 in