DegronMD

Uniprot ID: Q76NI1

Source protein: Kinase non-catalytic C-lobe domain-containing protein 1

Source gene: KNDC1

Class: LIG_APCC_ABBA_1

Location: 1426:1431

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8898

ASA_SCORE: 107.05

COIL: 0.9293

CONS_SCORE: 0.349

DSS_SCORE: 0.3323

HELIX: 0.031

FCONS_SCORE: 0.8639

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1439T	TCGA-B5-A11F	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.1111
p.A1439T	DO43618	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.1111
p.R1432H	TCGA-B5-A1MV	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.3056
p.R1432H	DO43354	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.3056
p.G1423E	TCGA-D9-A6EC	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.25
p.G1423E	DO50291	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.25
p.T1435I	TCGA-EB-A41A	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.2222
p.T1435I	DO37429	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.2222
p.P1441H	TCGA-ER-A193	SKCM	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.0556
p.P1441H	DO47368	SKCM	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.0556
p.P1441S	TCGA-FI-A2D5	UCEC	TCGA	LPPHKE	LIG_APCC_ABBA_1	0.0556
p.P1441S	DO41331	UCEC	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.0556
p.A1438S	DO229019	LICA	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.1389
p.K1430E	DO229211	THCA	ICGC	LPPHKE	LIG_APCC_ABBA_1	0.591
p.E1431K	SIDM00915	Small Cell Lung Carcinoma	GDSC	LPPHKE	LIG_APCC_ABBA_1	0.7022
p.E1431K	NCI-H378	lung	COSMIC	LPPHKE	LIG_APCC_ABBA_1	0.7022
p.Y1434C	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LPPHKE	LIG_APCC_ABBA_1	0.25
p.Y1434C	ACH-001669	Leukemia	CCLE	LPPHKE	LIG_APCC_ABBA_1	0.25
p.Y1434C	ACH-002238	Leukemia	CCLE	LPPHKE	LIG_APCC_ABBA_1	0.25
p.Y1434C	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LPPHKE	LIG_APCC_ABBA_1	0.25
p.R1432C	SIDM00668	Non-Cancerous	GDSC	LPPHKE	LIG_APCC_ABBA_1	0.3056
p.R1432C	ACH-002245	Lymphoma	CCLE	LPPHKE	LIG_APCC_ABBA_1	0.3056
p.R1432C	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	LPPHKE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76NI1	Kinase non-catalytic C-lobe domain-containing protein 1	LIG_APCC_ABBA_1	1426:1431	LPPHKE	APC,CDC20,FZR1	0.8898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons