DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPYTFSP
Uniprot ID:
Q76NI1
Source protein:
Kinase non-catalytic C-lobe domain-containing protein 1
Source gene:
KNDC1
Class:
CBL_PTK
Location:
1688:1694
E3 ligase:
CBL
DEGRON score:
0.9296
ASA_SCORE:
68.6714
COIL:
0.9047
CONS_SCORE:
0.4283
DSS_SCORE:
0.3444
HELIX:
0.0167
FCONS_SCORE:
0.8782
RIG_SCORE:
0.7549
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q1704H
TCGA-BA-A6DA
HNSC
TCGA
NPYTFSP
CBL_PTK
0.0556
p.Q1704H
DO44448
HNSC
ICGC
NPYTFSP
CBL_PTK
0.0556
p.Y1701C
TCGA-BR-4184
STAD
TCGA
NPYTFSP
CBL_PTK
0.5833
p.Y1701C
DO38328
STAD
ICGC
NPYTFSP
CBL_PTK
0.5833
p.H1683R
TCGA-D8-A1XK
BRCA
TCGA
NPYTFSP
CBL_PTK
0.1944
p.H1683R
DO4749
BRCA
ICGC
NPYTFSP
CBL_PTK
0.1944
p.A1684V
TCGA-E1-5318
LGG
TCGA
NPYTFSP
CBL_PTK
0.2222
p.A1684V
DO22195
LGG
ICGC
NPYTFSP
CBL_PTK
0.2222
p.H1683Y
TCGA-F7-A624
HNSC
TCGA
NPYTFSP
CBL_PTK
0.1944
p.H1683Y
DO44440
HNSC
ICGC
NPYTFSP
CBL_PTK
0.1944
p.Y1690C
TCGA-F7-A624
HNSC
TCGA
NPYTFSP
CBL_PTK
0.7087
p.Y1690C
DO44440
HNSC
ICGC
NPYTFSP
CBL_PTK
0.7087
p.P1696H
TCGA-GN-A26C
SKCM
TCGA
NPYTFSP
CBL_PTK
0.2778
p.P1696H
DO37782
SKCM
ICGC
NPYTFSP
CBL_PTK
0.2778
p.S1693R
DO224818
BRCA
ICGC
NPYTFSP
CBL_PTK
0.6316
p.L1698I
DO233266
GACA
ICGC
NPYTFSP
CBL_PTK
0.2222
p.A1684T
DO233748
GACA
ICGC
NPYTFSP
CBL_PTK
0.2222
p.K1703N
DO228976
LICA
ICGC
NPYTFSP
CBL_PTK
0.1944
p.S1693I
DO229019
LICA
ICGC
NPYTFSP
CBL_PTK
0.623
p.S1680R
DO232919
PEME
ICGC
NPYTFSP
CBL_PTK
0.1111
Drug responses associated with KNDC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPYTFSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q76NI1
Kinase non-catalytic C-lobe domain-containing protein 1
CBL_PTK
1688:1694
NPYTFSP
CBL
0.9296
More...