DegronMD

Uniprot ID: Q76NI1

Source protein: Kinase non-catalytic C-lobe domain-containing protein 1

Source gene: KNDC1

Class: DEG_SCF_FBW7_2

Location: 847:854

E3 ligase: FBXW7

DEGRON score: 0.9711

ASA_SCORE: 73.1875

COIL: 0.9345

CONS_SCORE: 0.3595

DSS_SCORE: 0.9434

HELIX: 0.0214

FCONS_SCORE: 0.9676

RIG_SCORE: 0.4702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S859I	TCGA-CR-7364	HNSC	TCGA	PGATPAGE	DEG_SCF_FBW7_2	0.1944
p.S859I	DO15679	HNSC	ICGC	PGATPAGE	DEG_SCF_FBW7_2	0.1944
p.G848E	DO50970	LICA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	0.6087
p.D856G	DO50966	LICA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	0.2778
p.G853E	DO222702	MELA	ICGC	PGATPAGE	DEG_SCF_FBW7_2	0.6087
p.D857E	SIDM00672	Hepatocellular Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM00969	Ovarian Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM00525	Osteosarcoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.D857E	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.25
p.G848R	SIDM00980	Gastric Carcinoma	GDSC	PGATPAGE	DEG_SCF_FBW7_2	0.6457
p.E843A	ACH-000515	Lung Cancer	CCLE	PGATPAGE	DEG_SCF_FBW7_2	0.2222
p.R839H	ACH-001536	Bile Duct Cancer	CCLE	PGATPAGE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76NI1	Kinase non-catalytic C-lobe domain-containing protein 1	DEG_SCF_FBW7_2	847:854	PGATPAGE	FBXW7	0.9711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons