DegronMD

Uniprot ID: O75071

Source protein: EF-hand calcium-binding domain-containing protein 14

Source gene: EFCAB14

Class: DEG_APCC_DBOX_1

Location: 338:346

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5444

ASA_SCORE: 102.7111

COIL: 0.346

CONS_SCORE: 0.7252

DSS_SCORE: 0.4934

HELIX: 0.6414

FCONS_SCORE: 1.0341

RIG_SCORE: 0.7429

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K338E	TCGA-AA-3949	COAD	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	0.591
p.R339I	TCGA-CA-6718	COAD	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	0.8102
p.Q355K	TCGA-FS-A1ZN	SKCM	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	0.0833
p.D332H	TCGA-XF-AAN0	BLCA	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	0.1667
p.Q333K	DO229029	LICA	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	0.1944
p.D330N	DO229240	THCA	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	0.1111
p.A343T	DO42280	UCEC	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	0.7139
p.T336N	SIDM00377	Other Sarcomas	GDSC	KRQSLDQVT	DEG_APCC_DBOX_1	0.2778
p.T336N	ACH-001655	Endometrial/Uterine Cancer	CCLE	KRQSLDQVT	DEG_APCC_DBOX_1	0.2778
p.T336N	SKN	soft_tissue	COSMIC	KRQSLDQVT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75071	EF-hand calcium-binding domain-containing protein 14	DEG_APCC_DBOX_1	338:346	KRQSLDQVT	APC,CDC20,FZR1	0.5444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons