DegronMD - O75071(EFCAB14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S365F	TCGA-A5-A0G2	UCEC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation blocking phosphorylation signal	0.6389
p.K338E	TCGA-AA-3949	COAD	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.591
p.L374P	TCGA-B5-A3FC	UCEC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7582
p.R339I	TCGA-CA-6718	COAD	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.8102
p.Q355K	TCGA-FS-A1ZN	SKCM	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.0833
p.K369E	TCGA-RC-A7SH	LIHC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.3056
p.D332H	TCGA-XF-AAN0	BLCA	TCGA	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1667
p.R385T	DO51859	BLCA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1389
p.W384C	DO49797	BLCA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1667
p.S370C	DO15455	HNSC	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7541
p.N386K	DO228952	LICA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.1111
p.Q333K	DO229029	LICA	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1944
p.Q375H	DO23744	LUAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.647
p.G368A	DO23915	LUAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation blocking phosphorylation signal	0.7222
p.P382L	DO37831	SKCM	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.2222
p.T376A	DO50291	SKCM	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation altering degron motif	0.7139
p.L379R	DO222392	STAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	370:378	Mutation rewiring degron network	0.3056
p.D330N	DO229240	THCA	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.1111
p.A343T	DO42280	UCEC	ICGC	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation altering degron motif	0.7139
p.T336N	SIDM00377	Other Sarcomas	GDSC	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2778
p.T336N	ACH-001655	Endometrial/Uterine Cancer	CCLE	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2778
p.T336N	SKN	soft tissue	COSMIC	KRQSLDQVT	DEG_APCC_DBOX_1	338:346	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB14

UniProt ID: O75071

Entrez ID: 9813

Protein name: EF-hand calcium-binding domain-containing protein 14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFCAB14 in