DegronMD

Uniprot ID: O75071

Source protein: EF-hand calcium-binding domain-containing protein 14

Source gene: EFCAB14

Class: DEG_APCC_DBOX_1

Location: 370:378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.75

ASA_SCORE: 95.4222

COIL: 0.0868

CONS_SCORE: 0.7341

DSS_SCORE: 0.5027

HELIX: 0.9108

FCONS_SCORE: 1.0135

RIG_SCORE: 0.7681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S365F	TCGA-A5-A0G2	UCEC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	0.6389
p.L374P	TCGA-B5-A3FC	UCEC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	0.7582
p.K369E	TCGA-RC-A7SH	LIHC	TCGA	LREKLQLIS	DEG_APCC_DBOX_1	0.3056
p.R385T	DO51859	BLCA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.1389
p.W384C	DO49797	BLCA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.1667
p.S370C	DO15455	HNSC	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.7541
p.N386K	DO228952	LICA	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.1111
p.Q375H	DO23744	LUAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.647
p.G368A	DO23915	LUAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.7222
p.P382L	DO37831	SKCM	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.2222
p.T376A	DO50291	SKCM	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.7139
p.L379R	DO222392	STAD	ICGC	LREKLQLIS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75071	EF-hand calcium-binding domain-containing protein 14	DEG_APCC_DBOX_1	370:378	LREKLQLIS	APC,CDC20,FZR1	0.75	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons