DegronMD

Uniprot ID: A2RUR9

Source protein: Coiled-coil domain-containing protein 144A

Source gene: CCDC144A

Class: DEG_APCC_DBOX_1

Location: 1353:1361

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7638

ASA_SCORE: 95.4222

COIL: 0.6657

CONS_SCORE: 0.6815

DSS_SCORE: 0.4624

HELIX: 0.3071

FCONS_SCORE: 0.9996

RIG_SCORE: 0.7539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1356D	TCGA-06-5416	GBM	TCGA	KRSALKDME	DEG_APCC_DBOX_1	0.6682
p.A1356D	DO10880	GBM	ICGC	KRSALKDME	DEG_APCC_DBOX_1	0.6682
p.K1366E	TCGA-5P-A9K2	KIRP	TCGA	KRSALKDME	DEG_APCC_DBOX_1	0.3056
p.K1366E	DO223947	KIRP	ICGC	KRSALKDME	DEG_APCC_DBOX_1	0.3056
p.L1364F	SIDM02077	Colorectal Carcinoma	GDSC	KRSALKDME	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUR9	Coiled-coil domain-containing protein 144A	DEG_APCC_DBOX_1	1353:1361	KRSALKDME	APC,CDC20,FZR1	0.7638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons