DegronMD

Uniprot ID: Q9HD15

Source protein: Steroid receptor RNA activator 1

Source gene: SRA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 193:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8383

ASA_SCORE: 91.0857

COIL: 0.4123

CONS_SCORE: 0.8694

DSS_SCORE: 0.3335

HELIX: 0.5809

FCONS_SCORE: 1.2696

RIG_SCORE: 0.7927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L183I	TCGA-18-3412	LUSC	TCGA	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L183I	TCGA-23-1121	OV	TCGA	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L183I	DO26552	LUSC	ICGC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L183I	DO28731	OV	ICGC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E190Q	TCGA-92-8065	LUSC	TCGA	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.E190Q	DO27074	LUSC	ICGC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R206M	TCGA-A5-A0G2	UCEC	TCGA	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R206M	DO41235	UCEC	ICGC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.E190K	TCGA-AC-A5XS	BRCA	TCGA	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.E190K	DO50023	BRCA	ICGC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R200T	SIDM00684	Glioblastoma	GDSC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R200T	LN-229	central_nervous_system	COSMIC	KRSLFSE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD15	Steroid receptor RNA activator 1	LIG_APCC_ABBAyCdc20_2	193:199	KRSLFSE	APC,CDC20,FZR1	0.8383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons