DegronMD

Uniprot ID: O43520

Source protein: Phospholipid-transporting ATPase IC

Source gene: ATP8B1

Class: DEG_APCC_DBOX_1

Location: 1230:1238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 92.1778

COIL: 0.8098

CONS_SCORE: 0.5014

DSS_SCORE: 0.4164

HELIX: 0.1421

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1247L	TCGA-91-6831	LUAD	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	0.0833
p.R1247L	DO23753	LUAD	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.0833
p.S1223F	TCGA-E7-A6MD	BLCA	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	0.1389
p.S1223F	DO219015	BLCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.1389
p.E1244K	TCGA-FD-A5BX	BLCA	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	0.1667
p.E1244K	DO44079	BLCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.1667
p.A1243V	TCGA-J9-A52C	PRAD	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	0.1944
p.A1243V	DO51343	PRAD	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.1944
p.R1231S	DO229009	LICA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.7427
p.R1247H	DO232224	PBCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	0.0833
p.A1239V	SIDM00216	Colorectal Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	0.3056
p.A1239V	ACH-000989	Colon/Colorectal Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	0.3056
p.A1239V	SNU-175	large_intestine	COSMIC	KRSPLDAIV	DEG_APCC_DBOX_1	0.3056
p.R1225H	SIDM00272	Breast Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	0.1944
p.R1225H	ACH-000910	Breast Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	0.1944
p.R1225H	MDA-MB-453	breast	COSMIC	KRSPLDAIV	DEG_APCC_DBOX_1	0.1944
p.S1232W	SIDM01682	Gastric Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	0.7874
p.S1232W	ACH-000110	Gastric Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	0.7874

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43520	Phospholipid-transporting ATPase IC	DEG_APCC_DBOX_1	1230:1238	KRSPLDAIV	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons