DegronMD - O43520(ATP8B1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1247L	TCGA-91-6831	LUAD	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.0833
p.R1247L	DO23753	LUAD	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.0833
p.D35E	TCGA-AP-A051	UCEC	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.0833
p.D35E	DO42673	UCEC	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.0833
p.E30K	TCGA-BH-A0B6	BRCA	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.2222
p.E30K	DO2641	BRCA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.2222
p.D26Y	TCGA-D5-6534	COAD	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation altering degron motif	0.7325
p.D26Y	DO10718	COAD	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation altering degron motif	0.7325
p.E32D	TCGA-D7-A6F0	STAD	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1667
p.E32D	DO50120	STAD	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1667
p.E20K	TCGA-D9-A6EC	SKCM	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.3056
p.E20K	TCGA-FI-A2D0	UCEC	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.3056
p.E20K	DO50291	SKCM	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.3056
p.E20K	DO43891	UCEC	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.3056
p.S1223F	TCGA-E7-A6MD	BLCA	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1389
p.S1223F	DO219015	BLCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1389
p.E1244K	TCGA-FD-A5BX	BLCA	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1667
p.E1244K	DO44079	BLCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1667
p.D34H	TCGA-G2-AA3B	BLCA	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1111
p.D34H	DO51882	BLCA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1111
p.A1243V	TCGA-J9-A52C	PRAD	TCGA	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1944
p.A1243V	DO51343	PRAD	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1944
p.Q16E	TCGA-VS-A9UY	CESC	TCGA	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1944
p.Q16E	DO219742	CESC	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1944
p.P17T	DO228948	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.2222
p.P17T	DO229009	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.2222
p.T29K	DO228952	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.25
p.D12E	DO228978	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.0833
p.D12E	SIDM01529	Bladder Carcinoma	GDSC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.0833
p.D12E	ACH-000011	Bladder Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.0833
p.P17H	DO228986	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.2222
p.R1231S	DO229009	LICA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation altering degron motif	0.7427
p.R1247H	DO232224	PBCA	ICGC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.0833
p.A1239V	SIDM00216	Colorectal Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.3056
p.A1239V	ACH-000989	Colon/Colorectal Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.3056
p.A1239V	SNU-175	large intestine	COSMIC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.3056
p.E32K	SIDM00545	Melanoma	GDSC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1667
p.E32K	ACH-000987	Skin Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1667
p.E32K	Mewo	skin	COSMIC	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1667
p.R1225H	SIDM00272	Breast Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1944
p.R1225H	ACH-000910	Breast Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1944
p.R1225H	MDA-MB-453	breast	COSMIC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation rewiring degron network	0.1944
p.S1232W	SIDM01682	Gastric Carcinoma	GDSC	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation altering degron motif	0.7874
p.S1232W	ACH-000110	Gastric Cancer	CCLE	KRSPLDAIV	DEG_APCC_DBOX_1	1230:1238	Mutation altering degron motif	0.7874
p.D34N	ACH-000892	Lung Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.1111
p.D27E	ACH-001853	Bile Duct Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	21:26	Mutation rewiring degron network	0.3056

Kaplan plot for ATP8B1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP8B1

UniProt ID: O43520

Entrez ID: 5205

Protein name: Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP8B1 in