DegronMD

Uniprot ID: O43520

Source protein: Phospholipid-transporting ATPase IC

Source gene: ATP8B1

Class: LIG_APCC_ABBA_1

Location: 21:26

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8576

ASA_SCORE: 85.5667

COIL: 0.8828

CONS_SCORE: 0.4529

DSS_SCORE: 0.9168

HELIX: 0.031

FCONS_SCORE: 1.215

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D35E	TCGA-AP-A051	UCEC	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.0833
p.D35E	DO42673	UCEC	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.0833
p.E30K	TCGA-BH-A0B6	BRCA	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.2222
p.E30K	DO2641	BRCA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.2222
p.D26Y	TCGA-D5-6534	COAD	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.7325
p.D26Y	DO10718	COAD	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.7325
p.E32D	TCGA-D7-A6F0	STAD	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.1667
p.E32D	DO50120	STAD	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.1667
p.E20K	TCGA-D9-A6EC	SKCM	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.3056
p.E20K	TCGA-FI-A2D0	UCEC	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.3056
p.E20K	DO50291	SKCM	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.3056
p.E20K	DO43891	UCEC	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.3056
p.D34H	TCGA-G2-AA3B	BLCA	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.1111
p.D34H	DO51882	BLCA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.1111
p.Q16E	TCGA-VS-A9UY	CESC	TCGA	VVPYSD	LIG_APCC_ABBA_1	0.1944
p.Q16E	DO219742	CESC	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.1944
p.P17T	DO228948	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.2222
p.P17T	DO229009	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.2222
p.T29K	DO228952	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.25
p.D12E	DO228978	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.0833
p.D12E	SIDM01529	Bladder Carcinoma	GDSC	VVPYSD	LIG_APCC_ABBA_1	0.0833
p.D12E	ACH-000011	Bladder Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	0.0833
p.P17H	DO228986	LICA	ICGC	VVPYSD	LIG_APCC_ABBA_1	0.2222
p.E32K	SIDM00545	Melanoma	GDSC	VVPYSD	LIG_APCC_ABBA_1	0.1667
p.E32K	ACH-000987	Skin Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	0.1667
p.E32K	Mewo	skin	COSMIC	VVPYSD	LIG_APCC_ABBA_1	0.1667
p.D34N	ACH-000892	Lung Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	0.1111
p.D27E	ACH-001853	Bile Duct Cancer	CCLE	VVPYSD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43520	Phospholipid-transporting ATPase IC	LIG_APCC_ABBA_1	21:26	VVPYSD	APC,CDC20,FZR1	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVPYSD

Degron related mutations and impact score

Drug responses associated with ATP8B1 mutations

All proteins holding degron of VVPYSD