DegronMD

Uniprot ID: Q8IUG5

Source protein: Unconventional myosin-XVIIIb

Source gene: MYO18B

Class: DEG_APCC_DBOX_1

Location: 1192:1200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5596

ASA_SCORE: 63.7444

COIL: 0.4414

CONS_SCORE: 0.613

DSS_SCORE: 0.2298

HELIX: 0.2031

FCONS_SCORE: 1.2037

RIG_SCORE: 0.7972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1206S	TCGA-L5-A88Y	ESCA	TCGA	KRSRLHFIH	DEG_APCC_DBOX_1	0.1667
p.R1195W	DO233638	GACA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	0.7523
p.R1195W	DO233804	GACA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	0.7523
p.R1193S	DO229034	LICA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	0.7427
p.M1185L	SIDM00267	Biliary Tract Carcinoma	GDSC	KRSRLHFIH	DEG_APCC_DBOX_1	0.1389
p.M1185L	ACH-002312	Gallbladder Cancer	CCLE	KRSRLHFIH	DEG_APCC_DBOX_1	0.1389
p.M1185L	TGBC24TKB	biliary_tract	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	0.1389
p.S1210I	RH-1	soft_tissue	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	0.0556
p.M1184L	TGBC24TKB	biliary_tract	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUG5	Unconventional myosin-XVIIIb	DEG_APCC_DBOX_1	1192:1200	KRSRLHFIH	APC,CDC20,FZR1	0.5596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons