DegronMD - Q8IUG5(MYO18B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2471A	TCGA-22-5483	LUSC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.0556
p.S2471A	DO26614	LUSC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.0556
p.P2496L	TCGA-50-6590	LUAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1389
p.P2496L	DO24692	LUAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1389
p.R2482H	TCGA-AG-A002	READ	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.R2482H	TCGA-E6-A1LX	UCEC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.R2482H	DO233884	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.R2482H	DO41020	UCEC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.P2498S	TCGA-BC-A10Z	LIHC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.0833
p.P2498S	DO23043	LIHC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.0833
p.T2477M	TCGA-CG-5723	STAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2222
p.T2477M	DO233245	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2222
p.T2477M	DO233882	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2222
p.T2477M	DO38376	STAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2222
p.E2497G	TCGA-CG-5733	STAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1111
p.E2497G	DO38551	STAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1111
p.S2483Y	TCGA-CQ-A4C9	HNSC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6009
p.S2483Y	DO49041	HNSC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6009
p.S2486L	TCGA-EB-A51B	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6556
p.S2486L	DO47343	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6556
p.E2479K	TCGA-EE-A2MR	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2778
p.E2479K	DO37819	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.2778
p.L2485F	TCGA-ER-A19D	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6981
p.L2485F	DO37750	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6981
p.E2497D	TCGA-IB-7651	PAAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1111
p.E2497D	DO46657	PAAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1111
p.P1206S	TCGA-L5-A88Y	ESCA	TCGA	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.1667
p.G2487A	DO233233	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.6429
p.R1195W	DO233638	GACA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation altering degron motif	0.7523
p.R1195W	DO233804	GACA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation altering degron motif	0.7523
p.R2482L	DO229028	LICA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8428
p.R1193S	DO229034	LICA	ICGC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation altering degron motif	0.7427
p.E2476K	DO229456	SKCA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation rewiring degron network	0.1944
p.M1185L	SIDM00267	Biliary Tract Carcinoma	GDSC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.1389
p.M1185L	ACH-002312	Gallbladder Cancer	CCLE	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.1389
p.M1185L	TGBC24TKB	biliary tract	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.1389
p.R2483H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.R2483H	ACH-000925	Lung Cancer	CCLE	NRSFLSGIK	DEG_APCC_DBOX_1	2481:2489	Mutation altering degron motif	0.8244
p.S1210I	RH-1	soft tissue	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.0556
p.M1184L	TGBC24TKB	biliary tract	COSMIC	KRSRLHFIH	DEG_APCC_DBOX_1	1192:1200	Mutation rewiring degron network	0.1111

Kaplan plot for MYO18B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO18B

UniProt ID: Q8IUG5

Entrez ID: 84700

Protein name: Unconventional myosin-XVIIIb

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYO18B in