DegronMD

Uniprot ID: Q8IUG5

Source protein: Unconventional myosin-XVIIIb

Source gene: MYO18B

Class: DEG_APCC_DBOX_1

Location: 2481:2489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7773

ASA_SCORE: 86.3556

COIL: 0.6678

CONS_SCORE: 0.3258

DSS_SCORE: 0.4974

HELIX: 0.2773

FCONS_SCORE: 1.0125

RIG_SCORE: 0.7277

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2471A	TCGA-22-5483	LUSC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.0556
p.S2471A	DO26614	LUSC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.0556
p.P2496L	TCGA-50-6590	LUAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.1389
p.P2496L	DO24692	LUAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.1389
p.R2482H	TCGA-AG-A002	READ	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244
p.R2482H	TCGA-E6-A1LX	UCEC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244
p.R2482H	DO233884	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244
p.R2482H	DO41020	UCEC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244
p.P2498S	TCGA-BC-A10Z	LIHC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.0833
p.P2498S	DO23043	LIHC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.0833
p.T2477M	TCGA-CG-5723	STAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.2222
p.T2477M	DO233245	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.2222
p.T2477M	DO233882	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.2222
p.T2477M	DO38376	STAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.2222
p.E2497G	TCGA-CG-5733	STAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.1111
p.E2497G	DO38551	STAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.1111
p.S2483Y	TCGA-CQ-A4C9	HNSC	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.6009
p.S2483Y	DO49041	HNSC	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.6009
p.S2486L	TCGA-EB-A51B	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.6556
p.S2486L	DO47343	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.6556
p.E2479K	TCGA-EE-A2MR	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.2778
p.E2479K	DO37819	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.2778
p.L2485F	TCGA-ER-A19D	SKCM	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.6981
p.L2485F	DO37750	SKCM	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.6981
p.E2497D	TCGA-IB-7651	PAAD	TCGA	NRSFLSGIK	DEG_APCC_DBOX_1	0.1111
p.E2497D	DO46657	PAAD	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.1111
p.G2487A	DO233233	GACA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.6429
p.R2482L	DO229028	LICA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.8428
p.E2476K	DO229456	SKCA	ICGC	NRSFLSGIK	DEG_APCC_DBOX_1	0.1944
p.R2483H	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244
p.R2483H	ACH-000925	Lung Cancer	CCLE	NRSFLSGIK	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRSFLSGIK

Degron related mutations and impact score

Drug responses associated with MYO18B mutations

All proteins holding degron of NRSFLSGIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUG5	Unconventional myosin-XVIIIb	DEG_APCC_DBOX_1	2481:2489	NRSFLSGIK	APC,CDC20,FZR1	0.7773	More...