DegronMD

Uniprot ID: O95810

Source protein: Caveolae-associated protein 2

Source gene: CAVIN2

Class: DEG_APCC_DBOX_1

Location: 232:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9502

ASA_SCORE: 105.1778

COIL: 0.3942

CONS_SCORE: 1

DSS_SCORE: 0.4027

HELIX: 0.5868

FCONS_SCORE: 1.0966

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E225V	SIDM01955	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1389
p.D240H	SIDM00507	Other Solid Cancers	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.6577
p.D240H	COR-L321	NS	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	0.6577
p.A228T	SIDM00836	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.2222
p.A228T	SW403	large_intestine	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	0.2222
p.R248C	SIDM00118	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1111
p.R248C	SIDM01588	Endometrial Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1111
p.R248C	HCC2998	large_intestine	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1111
p.R248L	SIDM01318	Hepatocellular Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1111
p.E224D	BEN	lung	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95810	Caveolae-associated protein 2	DEG_APCC_DBOX_1	232:240	KRSSLKKVD	APC,CDC20,FZR1	0.9502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons