DegronMD - O95810(CAVIN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S27G	SIDM01314	Colorectal Carcinoma	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	30:37	Mutation blocking phosphorylation signal	0.6944
p.E225V	SIDM01955	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1389
p.P36R	SIDM00007	Other Solid Cancers	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	30:37	Mutation altering degron motif	0.6401
p.P36R	MCC13	skin	COSMIC	PSSTPSPS	DEG_SCF_FBW7_1	30:37	Mutation altering degron motif	0.6401
p.D240H	SIDM00507	Other Solid Cancers	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.6577
p.D240H	COR-L321	NS	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.6577
p.G41V	SIDM00487	Colorectal Carcinoma	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	30:37	Mutation rewiring degron network	0.2222
p.G41V	CCK-81	large intestine	COSMIC	PSSTPSPS	DEG_SCF_FBW7_1	30:37	Mutation rewiring degron network	0.2222
p.A228T	SIDM00836	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.2222
p.A228T	SW403	large intestine	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.2222
p.R248C	SIDM00118	Colorectal Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.R248C	SIDM01588	Endometrial Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.R248C	HCC2998	large intestine	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.R248L	SIDM01318	Hepatocellular Carcinoma	GDSC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111
p.E224D	BEN	lung	COSMIC	KRSSLKKVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1111

Kaplan plot for CAVIN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAVIN2

UniProt ID: O95810

Entrez ID: 8436

Protein name: Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAVIN2 in