DegronMD

Uniprot ID: O95810

Source protein: Caveolae-associated protein 2

Source gene: CAVIN2

Class: DEG_SCF_FBW7_1

Location: 30:37

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 81.5625

COIL: 0.9403

CONS_SCORE: 0.667

DSS_SCORE: 0.7851

HELIX: 0.0427

FCONS_SCORE: 1.2532

RIG_SCORE: 0.5088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27G	SIDM01314	Colorectal Carcinoma	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	0.6944
p.P36R	SIDM00007	Other Solid Cancers	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	0.6401
p.P36R	MCC13	skin	COSMIC	PSSTPSPS	DEG_SCF_FBW7_1	0.6401
p.G41V	SIDM00487	Colorectal Carcinoma	GDSC	PSSTPSPS	DEG_SCF_FBW7_1	0.2222
p.G41V	CCK-81	large_intestine	COSMIC	PSSTPSPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95810	Caveolae-associated protein 2	DEG_SCF_FBW7_1	30:37	PSSTPSPS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons