DegronMD

Uniprot ID: Q12829

Source protein: Ras-related protein Rab-40B

Source gene: RAB40B

Class: DEG_APCC_DBOX_1

Location: 250:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.976

ASA_SCORE: 111.7667

COIL: 0.7122

CONS_SCORE: 0.3349

DSS_SCORE: 0.6718

HELIX: 0.212

FCONS_SCORE: 1.0377

RIG_SCORE: 0.7096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S265I	TCGA-FI-A2D5	UCEC	TCGA	KRSSLRKVK	DEG_APCC_DBOX_1	0.1389
p.R261C	TCGA-HF-A5NB	STAD	TCGA	KRSSLRKVK	DEG_APCC_DBOX_1	0.25
p.R255H	DO233898	GACA	ICGC	KRSSLRKVK	DEG_APCC_DBOX_1	0.7133
p.R261S	DO229221	THCA	ICGC	KRSSLRKVK	DEG_APCC_DBOX_1	0.25
p.K256N	SIDM00516	Melanoma	GDSC	KRSSLRKVK	DEG_APCC_DBOX_1	0.5806
p.K256N	MZ7-mel	skin	COSMIC	KRSSLRKVK	DEG_APCC_DBOX_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12829	Ras-related protein Rab-40B	DEG_APCC_DBOX_1	250:258	KRSSLRKVK	APC,CDC20,FZR1	0.976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons