DegronMD

Uniprot ID: Q5VZ89

Source protein: DENN domain-containing protein 4C

Source gene: DENND4C

Class: DEG_APCC_DBOX_1

Location: 1181:1189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9618

ASA_SCORE: 80.4

COIL: 0.6571

CONS_SCORE: 0.3187

DSS_SCORE: 0.3233

HELIX: 0.1909

FCONS_SCORE: 1.0059

RIG_SCORE: 0.7548

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1188M	TCGA-24-2024	OV	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.6507
p.I1188M	DO32237	OV	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.6507
p.D1177Y	TCGA-AZ-4315	COAD	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.2222
p.D1177Y	DO8842	COAD	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.2222
p.R1182I	TCGA-B5-A0JY	UCEC	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.8102
p.R1182I	DO43041	UCEC	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.8102
p.R1182I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRSSLYGIA	DEG_APCC_DBOX_1	0.8102
p.S1184T	TCGA-C8-A27B	BRCA	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.7116
p.S1184T	DO4623	BRCA	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.7116
p.V1174L	TCGA-CA-6717	COAD	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.1389
p.V1174L	DO8264	COAD	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.1389
p.K1181N	TCGA-DK-A3WW	BLCA	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.5806
p.K1181N	DO481	BLCA	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.5806
p.S1175F	TCGA-ER-A2NC	SKCM	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.1667
p.S1175F	DO47318	SKCM	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.1667
p.V1174I	TCGA-FI-A2D0	UCEC	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	0.1389
p.V1174I	DO43891	UCEC	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	0.1389
p.P1190S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	KRSSLYGIA	DEG_APCC_DBOX_1	0.3056
p.R1173G	SIDM01045	Endometrial Carcinoma	GDSC	KRSSLYGIA	DEG_APCC_DBOX_1	0.1111
p.R1173G	EN	endometrium	COSMIC	KRSSLYGIA	DEG_APCC_DBOX_1	0.1111
p.E1189Q	FADU	upper_aerodigestive_tract	COSMIC	KRSSLYGIA	DEG_APCC_DBOX_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ89	DENN domain-containing protein 4C	DEG_APCC_DBOX_1	1181:1189	KRSSLYGIA	APC,CDC20,FZR1	0.9618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons