DegronMD - Q5VZ89(DENND4C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1188M	TCGA-24-2024	OV	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.6507
p.I1188M	DO32237	OV	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.6507
p.P974S	TCGA-AA-3672	COAD	TCGA	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation rewiring degron network	0.1111
p.P974S	DO9010	COAD	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation rewiring degron network	0.1111
p.D1177Y	TCGA-AZ-4315	COAD	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.2222
p.D1177Y	DO8842	COAD	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.2222
p.P988L	TCGA-B5-A0JY	UCEC	TCGA	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation altering degron motif	0.7582
p.P988L	DO43041	UCEC	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation altering degron motif	0.7582
p.R1182I	TCGA-B5-A0JY	UCEC	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.8102
p.R1182I	DO43041	UCEC	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.8102
p.R1182I	ACH-000993	Endometrial/Uterine Cancer	CCLE	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.8102
p.S1184T	TCGA-C8-A27B	BRCA	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.7116
p.S1184T	DO4623	BRCA	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.7116
p.V1174L	TCGA-CA-6717	COAD	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1389
p.V1174L	DO8264	COAD	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1389
p.S1244R	TCGA-CG-5728	STAD	TCGA	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation blocking phosphorylation signal	0.5278
p.S1244R	DO38619	STAD	ICGC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation blocking phosphorylation signal	0.5278
p.G1264V	TCGA-CS-5393	LGG	TCGA	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1667
p.G1264V	DO22129	LGG	ICGC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1667
p.K1181N	TCGA-DK-A3WW	BLCA	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.5806
p.K1181N	DO481	BLCA	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.5806
p.S1175F	TCGA-ER-A2NC	SKCM	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1667
p.S1175F	DO47318	SKCM	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1667
p.V1174I	TCGA-FI-A2D0	UCEC	TCGA	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1389
p.V1174I	DO43891	UCEC	ICGC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1389
p.D993H	TCGA-MA-AA41	CESC	TCGA	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation rewiring degron network	0.2778
p.D993H	DO219723	CESC	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation rewiring degron network	0.2778
p.S1248C	DO230326	COCA	ICGC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation blocking phosphorylation signal	0.6389
p.S1251F	DO230336	COCA	ICGC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.2778
p.T1266A	DO234285	ESAD	ICGC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1111
p.S1000I	DO229019	LICA	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation blocking phosphorylation signal	0.5278
p.D993N	DO229050	LICA	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation rewiring degron network	0.2778
p.S1000G	DO46856	RECA	ICGC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation blocking phosphorylation signal	0.5278
p.G1263R	SIDM00454	Rhabdomyosarcoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00654	Small Cell Lung Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00690	Head and Neck Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00971	Breast Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00254	Neuroblastoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00863	Burkitt's Lymphoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.G1263R	SIDM00628	Breast Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1944
p.D1245G	SIDM01652	Non-Cancerous	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1111
p.D1245G	SIDM00187	Kidney Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	1253:1258	Mutation rewiring degron network	0.1111
p.P1190S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.3056
p.R1173G	SIDM01045	Endometrial Carcinoma	GDSC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1111
p.R1173G	EN	endometrium	COSMIC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation rewiring degron network	0.1111
p.S1000N	KYSE-270	oesophagus	COSMIC	SSIVKVPSGI	DEG_COP1_1	982:991	Mutation blocking phosphorylation signal	0.5278
p.E1189Q	FADU	upper aerodigestive tract	COSMIC	KRSSLYGIA	DEG_APCC_DBOX_1	1181:1189	Mutation altering degron motif	0.6744

Kaplan plot for DENND4C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND4C

UniProt ID: Q5VZ89

Entrez ID: 55667

Protein name: DENN domain-containing protein 4C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND4C in