DegronMD

Uniprot ID: Q5VZ89

Source protein: DENN domain-containing protein 4C

Source gene: DENND4C

Class: DEG_COP1_1

Location: 982:991

E3 ligase: COP1

DEGRON score: 0.9925

ASA_SCORE: 70.2

COIL: 0.7841

CONS_SCORE: 0.301

DSS_SCORE: 0.4212

HELIX: 0.0278

FCONS_SCORE: 0.9308

RIG_SCORE: 0.7258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P974S	TCGA-AA-3672	COAD	TCGA	SSIVKVPSGI	DEG_COP1_1	0.1111
p.P974S	DO9010	COAD	ICGC	SSIVKVPSGI	DEG_COP1_1	0.1111
p.P988L	TCGA-B5-A0JY	UCEC	TCGA	SSIVKVPSGI	DEG_COP1_1	0.7582
p.P988L	DO43041	UCEC	ICGC	SSIVKVPSGI	DEG_COP1_1	0.7582
p.D993H	TCGA-MA-AA41	CESC	TCGA	SSIVKVPSGI	DEG_COP1_1	0.2778
p.D993H	DO219723	CESC	ICGC	SSIVKVPSGI	DEG_COP1_1	0.2778
p.S1000I	DO229019	LICA	ICGC	SSIVKVPSGI	DEG_COP1_1	0.5278
p.D993N	DO229050	LICA	ICGC	SSIVKVPSGI	DEG_COP1_1	0.2778
p.S1000G	DO46856	RECA	ICGC	SSIVKVPSGI	DEG_COP1_1	0.5278
p.S1000N	KYSE-270	oesophagus	COSMIC	SSIVKVPSGI	DEG_COP1_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ89	DENN domain-containing protein 4C	DEG_COP1_1	982:991	SSIVKVPSGI	COP1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons