DegronMD

Uniprot ID: Q5VZ89

Source protein: DENN domain-containing protein 4C

Source gene: DENND4C

Class: LIG_APCC_ABBA_1

Location: 1253:1258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9865

ASA_SCORE: 99.1333

COIL: 0.3098

CONS_SCORE: 0.4247

DSS_SCORE: 0.6504

HELIX: 0.6775

FCONS_SCORE: 1.0777

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1244R	TCGA-CG-5728	STAD	TCGA	MELHRE	LIG_APCC_ABBA_1	0.5278
p.S1244R	DO38619	STAD	ICGC	MELHRE	LIG_APCC_ABBA_1	0.5278
p.G1264V	TCGA-CS-5393	LGG	TCGA	MELHRE	LIG_APCC_ABBA_1	0.1667
p.G1264V	DO22129	LGG	ICGC	MELHRE	LIG_APCC_ABBA_1	0.1667
p.S1248C	DO230326	COCA	ICGC	MELHRE	LIG_APCC_ABBA_1	0.6389
p.S1251F	DO230336	COCA	ICGC	MELHRE	LIG_APCC_ABBA_1	0.2778
p.T1266A	DO234285	ESAD	ICGC	MELHRE	LIG_APCC_ABBA_1	0.1111
p.G1263R	SIDM00454	Rhabdomyosarcoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00654	Small Cell Lung Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00690	Head and Neck Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00971	Breast Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00254	Neuroblastoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00863	Burkitt's Lymphoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.G1263R	SIDM00628	Breast Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1944
p.D1245G	SIDM01652	Non-Cancerous	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1111
p.D1245G	SIDM00187	Kidney Carcinoma	GDSC	MELHRE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ89	DENN domain-containing protein 4C	LIG_APCC_ABBA_1	1253:1258	MELHRE	APC,CDC20,FZR1	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons