DegronMD

Uniprot ID: Q8WU90

Source protein: Zinc finger CCCH domain-containing protein 15

Source gene: ZC3H15

Class: LIG_APCC_ABBAyCdc20_2

Location: 133:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.958

ASA_SCORE: 81.3857

COIL: 0.6079

CONS_SCORE: 0.9005

DSS_SCORE: 0.2485

HELIX: 0.2431

FCONS_SCORE: 1.3066

RIG_SCORE: 0.8167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R134Q	TCGA-A5-A2K3	UCEC	TCGA	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.6218
p.R134Q	DO230315	COCA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.6218
p.R134Q	DO43899	UCEC	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.6218
p.A140V	TCGA-AP-A1E1	UCEC	TCGA	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.A140V	DO43226	UCEC	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.3056
p.R141I	TCGA-EO-A22T	UCEC	TCGA	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.2778
p.R141I	DO42320	UCEC	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.2778
p.D142H	TCGA-OL-A5RW	BRCA	TCGA	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.25
p.D142H	DO44238	BRCA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.25
p.D139Y	DO225167	BRCA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.7325
p.M128I	DO228976	LICA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.1944
p.C131F	DO229019	LICA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.2778
p.D148H	DO50974	LICA	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.0833
p.Y137S	DO221118	MALY	ICGC	KRSVYID	LIG_APCC_ABBAyCdc20_2	0.8231

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU90	Zinc finger CCCH domain-containing protein 15	LIG_APCC_ABBAyCdc20_2	133:139	KRSVYID	APC,CDC20,FZR1	0.958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons