DegronMD

Uniprot ID: Q96BY7

Source protein: Autophagy-related protein 2 homolog B

Source gene: ATG2B

Class: LIG_APCC_ABBAyCdc20_2

Location: 1007:1013

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8946

ASA_SCORE: 85.9857

COIL: 0.7019

CONS_SCORE: 0.2993

DSS_SCORE: 0.301

HELIX: 0.172

FCONS_SCORE: 1.0859

RIG_SCORE: 0.7647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1014D	TCGA-21-1080	LUSC	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1014D	DO26502	LUSC	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T1022S	TCGA-A8-A07Z	BRCA	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.5278
p.T1022S	DO3311	BRCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.5278
p.E1015D	TCGA-FI-A2D5	UCEC	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1015D	DO41331	UCEC	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1014K	TCGA-GU-A764	BLCA	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1014K	DO51889	BLCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1016G	DO222798	COCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.6944
p.E1014G	DO228297	LICA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T1022N	DO229006	LICA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BY7	Autophagy-related protein 2 homolog B	LIG_APCC_ABBAyCdc20_2	1007:1013	KSAVHYD	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons