DegronMD - Q96BY7(ATG2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1014D	TCGA-21-1080	LUSC	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.3056
p.E1014D	DO26502	LUSC	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.3056
p.T1022S	TCGA-A8-A07Z	BRCA	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation blocking phosphorylation signal	0.5278
p.T1022S	DO3311	BRCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation blocking phosphorylation signal	0.5278
p.L1726H	TCGA-BQ-5886	KIRP	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.L1726H	DO20901	KIRP	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.T1749I	TCGA-BR-6452	STAD	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.T1749I	DO38404	STAD	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.T1749I	SIDM00282	Colorectal Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.T1749I	ACH-000998	Colon/Colorectal Cancer	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.T1749I	CW-2	large intestine	COSMIC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.F1722L	TCGA-EI-6917	READ	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.F1722L	DO36881	READ	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.0556
p.E1015D	TCGA-FI-A2D5	UCEC	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.2778
p.E1015D	DO41331	UCEC	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.2778
p.E1014K	TCGA-GU-A764	BLCA	TCGA	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.3056
p.E1014K	DO51889	BLCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.3056
p.S1016G	DO222798	COCA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation blocking phosphorylation signal	0.6944
p.E1014G	DO228297	LICA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation rewiring degron network	0.3056
p.T1735N	DO229027	LICA	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation altering degron motif	0.7055
p.T1022N	DO229006	LICA	ICGC	KSAVHYD	LIG_APCC_ABBAyCdc20_2	1007:1013	Mutation blocking phosphorylation signal	0.5278
p.K1741T	SIDM00845	Burkitt's Lymphoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.2778
p.K1741T	SIDM00461	Acute Myeloid Leukemia	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.2778
p.K1741T	SIDM01519	Head and Neck Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.2778
p.G1745E	SIDM00457	Plasma Cell Myeloma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.G1745E	SIDM01578	Bladder Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.G1745E	ACH-000024	Myeloma	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.G1745E	ACH-000057	Myeloma	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.G1745E	ACH-000862	Bladder Cancer	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667
p.G1745E	OPM-2	haematopoietic and lymphoid tissue	COSMIC	LQMTPDPE	DEG_SCF_FBW7_2	1732:1739	Mutation rewiring degron network	0.1667

Kaplan plot for ATG2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATG2B

UniProt ID: Q96BY7

Entrez ID: 55102

Protein name: Autophagy-related protein 2 homolog B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATG2B in