DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LQMTPDPE
Uniprot ID:
Q96BY7
Source protein:
Autophagy-related protein 2 homolog B
Source gene:
ATG2B
Class:
DEG_SCF_FBW7_2
Location:
1732:1739
E3 ligase:
FBXW7
DEGRON score:
0.8394
ASA_SCORE:
85.175
COIL:
0.7888
CONS_SCORE:
0.2917
DSS_SCORE:
0.4534
HELIX:
0.1748
FCONS_SCORE:
0.9928
RIG_SCORE:
0.7254
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L1726H
TCGA-BQ-5886
KIRP
TCGA
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.L1726H
DO20901
KIRP
ICGC
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.T1749I
TCGA-BR-6452
STAD
TCGA
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.T1749I
DO38404
STAD
ICGC
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.T1749I
SIDM00282
Colorectal Carcinoma
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.T1749I
ACH-000998
Colon/Colorectal Cancer
CCLE
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.T1749I
CW-2
large_intestine
COSMIC
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.F1722L
TCGA-EI-6917
READ
TCGA
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.F1722L
DO36881
READ
ICGC
LQMTPDPE
DEG_SCF_FBW7_2
0.0556
p.T1735N
DO229027
LICA
ICGC
LQMTPDPE
DEG_SCF_FBW7_2
0.7055
p.K1741T
SIDM00845
Burkitt's Lymphoma
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.2778
p.K1741T
SIDM00461
Acute Myeloid Leukemia
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.2778
p.K1741T
SIDM01519
Head and Neck Carcinoma
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.2778
p.G1745E
SIDM00457
Plasma Cell Myeloma
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.G1745E
SIDM01578
Bladder Carcinoma
GDSC
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.G1745E
ACH-000024
Myeloma
CCLE
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.G1745E
ACH-000057
Myeloma
CCLE
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.G1745E
ACH-000862
Bladder Cancer
CCLE
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
p.G1745E
OPM-2
haematopoietic_and_lymphoid_tissue
COSMIC
LQMTPDPE
DEG_SCF_FBW7_2
0.1667
Drug responses associated with ATG2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQMTPDPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96BY7
Autophagy-related protein 2 homolog B
DEG_SCF_FBW7_2
1732:1739
LQMTPDPE
FBXW7
0.8394
More...