DegronMD

Uniprot ID: Q96BY7

Source protein: Autophagy-related protein 2 homolog B

Source gene: ATG2B

Class: DEG_SCF_FBW7_2

Location: 1732:1739

E3 ligase: FBXW7

DEGRON score: 0.8394

ASA_SCORE: 85.175

COIL: 0.7888

CONS_SCORE: 0.2917

DSS_SCORE: 0.4534

HELIX: 0.1748

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7254

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1735N	DO229027	LICA	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	0.7055
p.K1741T	SIDM00845	Burkitt's Lymphoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.2778
p.K1741T	SIDM00461	Acute Myeloid Leukemia	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.2778
p.K1741T	SIDM01519	Head and Neck Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.2778
p.L1726H	TCGA-BQ-5886	KIRP	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.L1726H	DO20901	KIRP	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	SIDM00457	Plasma Cell Myeloma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	SIDM01578	Bladder Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	ACH-000024	Myeloma	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	ACH-000057	Myeloma	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	ACH-000862	Bladder Cancer	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.G1745E	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	LQMTPDPE	DEG_SCF_FBW7_2	0.1667
p.T1749I	TCGA-BR-6452	STAD	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.T1749I	DO38404	STAD	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.T1749I	SIDM00282	Colorectal Carcinoma	GDSC	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.T1749I	ACH-000998	Colon/Colorectal Cancer	CCLE	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.T1749I	CW-2	large_intestine	COSMIC	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.F1722L	TCGA-EI-6917	READ	TCGA	LQMTPDPE	DEG_SCF_FBW7_2	0.0556
p.F1722L	DO36881	READ	ICGC	LQMTPDPE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BY7	Autophagy-related protein 2 homolog B	DEG_SCF_FBW7_2	1732:1739	LQMTPDPE	FBXW7	0.8394	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons