DegronMD

Uniprot ID: Q96C24

Source protein: Synaptotagmin-like protein 4

Source gene: SYTL4

Class: LIG_APCC_ABBAyCdc20_2

Location: 220:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 85.3571

COIL: 0.8161

CONS_SCORE: 0.428

DSS_SCORE: 0.5247

HELIX: 0.1507

FCONS_SCORE: 1.0781

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P233S	TCGA-18-3409	LUSC	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P233S	DO26444	LUSC	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q236H	TCGA-CA-6717	COAD	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q236H	DO8264	COAD	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S213C	TCGA-HG-A9SC	CESC	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.5833
p.S213C	DO51603	CESC	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.5833
p.S235Y	TCGA-XF-A8HG	BLCA	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S235Y	DO49802	BLCA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S231F	DO222554	MELA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.6389
p.P225S	DO222904	MELA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.L223P	SIDM00609	Kidney Carcinoma	GDSC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L223P	ACH-000250	Kidney Cancer	CCLE	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.L223P	KMRC-20	kidney	COSMIC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.7582
p.A232S	SIDM00368	Small Cell Lung Carcinoma	GDSC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A232S	SBC-5	lung	COSMIC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C24	Synaptotagmin-like protein 4	LIG_APCC_ABBAyCdc20_2	220:226	KSGLFPE	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons