DegronMD - Q96C24(SYTL4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G332A	TCGA-17-Z022	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.0556
p.P233S	TCGA-18-3409	LUSC	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.1389
p.P233S	DO26444	LUSC	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.1389
p.N353Y	TCGA-38-4628	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1667
p.N353Y	DO26354	LUAD	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1667
p.T337M	TCGA-69-7978	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1944
p.T337M	DO24920	LUAD	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1944
p.S340N	TCGA-AP-A051	UCEC	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.7222
p.S340N	DO42673	UCEC	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.7222
p.G349V	TCGA-C9-A47Z	HNSC	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2778
p.G349V	DO44423	HNSC	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2778
p.Q236H	TCGA-CA-6717	COAD	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.0556
p.Q236H	DO8264	COAD	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.0556
p.G352W	TCGA-EE-A2GN	SKCM	TCGA	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1944
p.G352W	DO37896	SKCM	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.1944
p.S213C	TCGA-HG-A9SC	CESC	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation blocking phosphorylation signal	0.5833
p.S213C	DO51603	CESC	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation blocking phosphorylation signal	0.5833
p.S235Y	TCGA-XF-A8HG	BLCA	TCGA	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.0833
p.S235Y	DO49802	BLCA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.0833
p.G349D	DO50797	LICA	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2778
p.R340G	DO219549	LIHC	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation blocking phosphorylation signal	0.7222
p.M341I	DO220887	MELA	ICGC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.3056
p.S231F	DO222554	MELA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation blocking phosphorylation signal	0.6389
p.P225S	DO222904	MELA	ICGC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation altering degron motif	0.5641
p.L223P	SIDM00609	Kidney Carcinoma	GDSC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation altering degron motif	0.7582
p.L223P	ACH-000250	Kidney Cancer	CCLE	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation altering degron motif	0.7582
p.L223P	KMRC-20	kidney	COSMIC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation altering degron motif	0.7582
p.A232S	SIDM00368	Small Cell Lung Carcinoma	GDSC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.1667
p.A232S	SBC-5	lung	COSMIC	KSGLFPE	LIG_APCC_ABBAyCdc20_2	220:226	Mutation rewiring degron network	0.1667
p.S338Y	SNU-81	large intestine	COSMIC	MSIYSE	LIG_APCC_ABBA_1	342:347	Mutation rewiring degron network	0.2222

Kaplan plot for SYTL4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYTL4

UniProt ID: Q96C24

Entrez ID: 94121

Protein name: Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYTL4 in