DegronMD

Uniprot ID: Q96C24

Source protein: Synaptotagmin-like protein 4

Source gene: SYTL4

Class: LIG_APCC_ABBA_1

Location: 342:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5722

ASA_SCORE: 80.15

COIL: 0.4792

CONS_SCORE: 0.6001

DSS_SCORE: 0.1811

HELIX: 0.1673

FCONS_SCORE: 1.1303

RIG_SCORE: 0.7667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G332A	TCGA-17-Z022	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.0556
p.N353Y	TCGA-38-4628	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.1667
p.N353Y	DO26354	LUAD	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.1667
p.T337M	TCGA-69-7978	LUAD	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.1944
p.T337M	DO24920	LUAD	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.1944
p.S340N	TCGA-AP-A051	UCEC	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.7222
p.S340N	DO42673	UCEC	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.7222
p.G349V	TCGA-C9-A47Z	HNSC	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.2778
p.G349V	DO44423	HNSC	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.2778
p.G352W	TCGA-EE-A2GN	SKCM	TCGA	MSIYSE	LIG_APCC_ABBA_1	0.1944
p.G352W	DO37896	SKCM	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.1944
p.G349D	DO50797	LICA	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.2778
p.R340G	DO219549	LIHC	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.7222
p.M341I	DO220887	MELA	ICGC	MSIYSE	LIG_APCC_ABBA_1	0.3056
p.S338Y	SNU-81	large_intestine	COSMIC	MSIYSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96C24	Synaptotagmin-like protein 4	LIG_APCC_ABBA_1	342:347	MSIYSE	APC,CDC20,FZR1	0.5722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons