DegronMD

Uniprot ID: Q9BV73

Source protein: Centrosome-associated protein CEP250

Source gene: CEP250

Class: LIG_APCC_ABBAyCdc20_2

Location: 1280:1286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6528

ASA_SCORE: 103.5571

COIL: 0.0496

CONS_SCORE: 0.5937

DSS_SCORE: 0.5455

HELIX: 0.9514

FCONS_SCORE: 1.0969

RIG_SCORE: 0.7303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1272C	TCGA-DA-A1IC	SKCM	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T1276I	TCGA-ET-A2N5	THCA	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D1275H	TCGA-ZF-A9R7	BLCA	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1280L	DO228952	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R1280L	DO229018	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R1274L	DO229025	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R1275I	DO229045	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A1283S	DO229045	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.7588
p.A1283V	DO50804	LIRI	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.6936
p.R1287L	DO45269	LIRI	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R1274W	DO41871	UCEC	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q1291H	DO41361	UCEC	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1277G	SIDM00333	Endometrial Carcinoma	GDSC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E1277G	ACH-000988	Endometrial/Uterine Cancer	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E1277G	MFE-319	endometrium	COSMIC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.S1295C	SIDM00476	Ovarian Carcinoma	GDSC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.5278
p.S1295C	ACH-001373	Ovarian Cancer	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.5278
p.S1295C	OV-17R	ovary	COSMIC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.5278
p.L1287V	ACH-001134	Lymphoma	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV73	Centrosome-associated protein CEP250	LIG_APCC_ABBAyCdc20_2	1280:1286	KSQVHTE	APC,CDC20,FZR1	0.6528	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons