DegronMD - Q9BV73(CEP250)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L2111Q	TCGA-05-4382	LUAD	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation rewiring degron network	0.1389
p.G1722W	TCGA-17-Z031	LUAD	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation altering degron motif	0.6714
p.R1721H	TCGA-A5-A0G2	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation altering degron motif	0.8244
p.G1715S	TCGA-B8-5162	KIRC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.1944
p.E1725Q	TCGA-BB-4227	HNSC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation altering degron motif	0.5633
p.E1711Q	TCGA-CX-7085	HNSC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.0833
p.R1272C	TCGA-DA-A1IC	SKCM	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1111
p.Q1720L	TCGA-DD-AACQ	LIHC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation altering degron motif	0.6654
p.R2281W	TCGA-EE-A2MD	SKCM	TCGA	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1944
p.I1730S	TCGA-EO-A22R	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.2778
p.T1276I	TCGA-ET-A2N5	THCA	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.2222
p.R1732H	TCGA-EY-A549	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.2222
p.R1732H	SIDM02031	Esophageal Carcinoma	GDSC	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.2222
p.L2125V	TCGA-FI-A2D5	UCEC	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation altering degron motif	0.5654
p.Q1586K	TCGA-G9-6351	PRAD	TCGA	QRVALTHLT	DEG_APCC_DBOX_1	1586:1594	Mutation altering degron motif	0.5833
p.E2115D	TCGA-LN-A49M	ESCA	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation rewiring degron network	0.25
p.M2263I	TCGA-WE-A8K5	SKCM	TCGA	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1944
p.E1578D	TCGA-X6-A7WA	SARC	TCGA	QRVALTHLT	DEG_APCC_DBOX_1	1586:1594	Mutation rewiring degron network	0.1111
p.D1275H	TCGA-ZF-A9R7	BLCA	TCGA	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1944
p.I2269T	DO2813	BRCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.7078
p.G2282V	DO227709	COCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1667
p.Q1595R	DO227802	COCA	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	1586:1594	Mutation rewiring degron network	0.3056
p.R2260C	DO233882	GACA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1111
p.D2119G	DO12538	GBM	ICGC	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation altering degron motif	0.7198
p.D2281N	DO52027	HNSC	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1944
p.R1280L	DO228952	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation altering degron motif	0.8428
p.R1280L	DO229018	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation altering degron motif	0.8428
p.R1274L	DO229025	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1667
p.R1275I	DO229045	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1944
p.A1283S	DO229045	LICA	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation altering degron motif	0.7588
p.A1283V	DO50804	LIRI	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation altering degron motif	0.6936
p.R1287L	DO45269	LIRI	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.3056
p.R1580Q	DO51575	LUSC	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	1586:1594	Mutation rewiring degron network	0.1667
p.S2266F	DO220860	MELA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.2778
p.E2115K	DO222504	MELA	ICGC	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation rewiring degron network	0.25
p.A2261V	DO35591	PBCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1389
p.E1584K	DO43682	UCEC	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	1586:1594	Mutation rewiring degron network	0.2778
p.R1274W	DO41871	UCEC	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1667
p.Q1291H	DO41361	UCEC	ICGC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.1944
p.A2258V	DO41331	UCEC	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.0556
p.N2120D	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation altering degron motif	0.5821
p.N2120D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	QRNNLEALP	DEG_APCC_DBOX_1	2118:2126	Mutation altering degron motif	0.5821
p.E1277G	SIDM00333	Endometrial Carcinoma	GDSC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.25
p.E1277G	ACH-000988	Endometrial/Uterine Cancer	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.25
p.E1277G	MFE-319	endometrium	COSMIC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.25
p.W2268C	SIDM00493	Other Solid Cancers	GDSC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5889
p.W2268C	ACH-001075	Lung Cancer	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5889
p.W2268C	NCI-H292	lung	COSMIC	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5889
p.S1295C	SIDM00476	Ovarian Carcinoma	GDSC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation blocking phosphorylation signal	0.5278
p.S1295C	ACH-001373	Ovarian Cancer	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation blocking phosphorylation signal	0.5278
p.S1295C	OV-17R	ovary	COSMIC	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation blocking phosphorylation signal	0.5278
p.L1287V	ACH-001134	Lymphoma	CCLE	KSQVHTE	LIG_APCC_ABBAyCdc20_2	1280:1286	Mutation rewiring degron network	0.3056
p.M2263R	ACH-001632	Ovarian Cancer	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation rewiring degron network	0.1944
p.R1732G	ACH-001848	Bile Duct Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.2222
p.E2273D	ACH-001991	Primary	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	2268:2276	Mutation altering degron motif	0.5647
p.D1733N	ACH-002041	Thyroid Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation rewiring degron network	0.1944
p.K1734T	ACH-002446	Gastric Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	1720:1728	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP250

UniProt ID: Q9BV73

Entrez ID: 11190

Protein name: Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP250 in