DegronMD

Uniprot ID: Q9BV73

Source protein: Centrosome-associated protein CEP250

Source gene: CEP250

Class: DEG_APCC_DBOX_1

Location: 2118:2126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7702

ASA_SCORE: 106.5889

COIL: 0.222

CONS_SCORE: 0.5746

DSS_SCORE: 0.6416

HELIX: 0.7747

FCONS_SCORE: 1.0034

RIG_SCORE: 0.6403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2111Q	TCGA-05-4382	LUAD	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	0.1389
p.L2125V	TCGA-FI-A2D5	UCEC	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	0.5654
p.E2115D	TCGA-LN-A49M	ESCA	TCGA	QRNNLEALP	DEG_APCC_DBOX_1	0.25
p.D2119G	DO12538	GBM	ICGC	QRNNLEALP	DEG_APCC_DBOX_1	0.7198
p.E2115K	DO222504	MELA	ICGC	QRNNLEALP	DEG_APCC_DBOX_1	0.25
p.N2120D	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	QRNNLEALP	DEG_APCC_DBOX_1	0.5821
p.N2120D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	QRNNLEALP	DEG_APCC_DBOX_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV73	Centrosome-associated protein CEP250	DEG_APCC_DBOX_1	2118:2126	QRNNLEALP	APC,CDC20,FZR1	0.7702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons