DegronMD

Uniprot ID: Q9BV73

Source protein: Centrosome-associated protein CEP250

Source gene: CEP250

Class: DEG_APCC_DBOX_1

Location: 2268:2276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9262

ASA_SCORE: 114.3778

COIL: 0.0144

CONS_SCORE: 0.6099

DSS_SCORE: 0.4484

HELIX: 0.9857

FCONS_SCORE: 1.0509

RIG_SCORE: 0.7805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2281W	TCGA-EE-A2MD	SKCM	TCGA	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1944
p.M2263I	TCGA-WE-A8K5	SKCM	TCGA	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1944
p.I2269T	DO2813	BRCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.7078
p.G2282V	DO227709	COCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1667
p.R2260C	DO233882	GACA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1111
p.D2281N	DO52027	HNSC	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1944
p.S2266F	DO220860	MELA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.2778
p.A2261V	DO35591	PBCA	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1389
p.A2258V	DO41331	UCEC	ICGC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.0556
p.W2268C	SIDM00493	Other Solid Cancers	GDSC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.5889
p.W2268C	ACH-001075	Lung Cancer	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	0.5889
p.W2268C	NCI-H292	lung	COSMIC	WRQRLEHLQ	DEG_APCC_DBOX_1	0.5889
p.M2263R	ACH-001632	Ovarian Cancer	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	0.1944
p.E2273D	ACH-001991	Primary	CCLE	WRQRLEHLQ	DEG_APCC_DBOX_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV73	Centrosome-associated protein CEP250	DEG_APCC_DBOX_1	2268:2276	WRQRLEHLQ	APC,CDC20,FZR1	0.9262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons