DegronMD

Uniprot ID: Q9BV73

Source protein: Centrosome-associated protein CEP250

Source gene: CEP250

Class: DEG_APCC_DBOX_1

Location: 1586:1594

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5548

ASA_SCORE: 98.1778

COIL: 0.0253

CONS_SCORE: 0.6344

DSS_SCORE: 0.3909

HELIX: 0.9752

FCONS_SCORE: 1.0066

RIG_SCORE: 0.8009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1586K	TCGA-G9-6351	PRAD	TCGA	QRVALTHLT	DEG_APCC_DBOX_1	0.5833
p.E1578D	TCGA-X6-A7WA	SARC	TCGA	QRVALTHLT	DEG_APCC_DBOX_1	0.1111
p.Q1595R	DO227802	COCA	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	0.3056
p.R1580Q	DO51575	LUSC	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	0.1667
p.E1584K	DO43682	UCEC	ICGC	QRVALTHLT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV73	Centrosome-associated protein CEP250	DEG_APCC_DBOX_1	1586:1594	QRVALTHLT	APC,CDC20,FZR1	0.5548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons