DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QRGSLEHMK
Uniprot ID:
Q9BV73
Source protein:
Centrosome-associated protein CEP250
Source gene:
CEP250
Class:
DEG_APCC_DBOX_1
Location:
1720:1728
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8049
ASA_SCORE:
102.9889
COIL:
0.0194
CONS_SCORE:
0.6229
DSS_SCORE:
0.5857
HELIX:
0.9807
FCONS_SCORE:
1.1067
RIG_SCORE:
0.6736
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1722W
TCGA-17-Z031
LUAD
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.6714
p.R1721H
TCGA-A5-A0G2
UCEC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.8244
p.G1715S
TCGA-B8-5162
KIRC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.1944
p.E1725Q
TCGA-BB-4227
HNSC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.5633
p.E1711Q
TCGA-CX-7085
HNSC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.0833
p.Q1720L
TCGA-DD-AACQ
LIHC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.6654
p.I1730S
TCGA-EO-A22R
UCEC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.2778
p.R1732H
TCGA-EY-A549
UCEC
TCGA
QRGSLEHMK
DEG_APCC_DBOX_1
0.2222
p.R1732H
SIDM02031
Esophageal Carcinoma
GDSC
QRGSLEHMK
DEG_APCC_DBOX_1
0.2222
p.R1732G
ACH-001848
Bile Duct Cancer
CCLE
QRGSLEHMK
DEG_APCC_DBOX_1
0.2222
p.D1733N
ACH-002041
Thyroid Cancer
CCLE
QRGSLEHMK
DEG_APCC_DBOX_1
0.1944
p.K1734T
ACH-002446
Gastric Cancer
CCLE
QRGSLEHMK
DEG_APCC_DBOX_1
0.2778
Drug responses associated with CEP250 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRGSLEHMK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BV73
Centrosome-associated protein CEP250
DEG_APCC_DBOX_1
1720:1728
QRGSLEHMK
APC,CDC20,FZR1
0.8049
More...