DegronMD

Uniprot ID: Q9BV73

Source protein: Centrosome-associated protein CEP250

Source gene: CEP250

Class: DEG_APCC_DBOX_1

Location: 1720:1728

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8049

ASA_SCORE: 102.9889

COIL: 0.0194

CONS_SCORE: 0.6229

DSS_SCORE: 0.5857

HELIX: 0.9807

FCONS_SCORE: 1.1067

RIG_SCORE: 0.6736

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1721H	TCGA-A5-A0G2	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.8244
p.G1722W	TCGA-17-Z031	LUAD	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.6714
p.Q1720L	TCGA-DD-AACQ	LIHC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.6654
p.E1725Q	TCGA-BB-4227	HNSC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.5633
p.I1730S	TCGA-EO-A22R	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.2778
p.K1734T	ACH-002446	Gastric Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	0.2778
p.R1732H	TCGA-EY-A549	UCEC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.2222
p.R1732H	SIDM02031	Esophageal Carcinoma	GDSC	QRGSLEHMK	DEG_APCC_DBOX_1	0.2222
p.R1732G	ACH-001848	Bile Duct Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	0.2222
p.G1715S	TCGA-B8-5162	KIRC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.1944
p.D1733N	ACH-002041	Thyroid Cancer	CCLE	QRGSLEHMK	DEG_APCC_DBOX_1	0.1944
p.E1711Q	TCGA-CX-7085	HNSC	TCGA	QRGSLEHMK	DEG_APCC_DBOX_1	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BV73	Centrosome-associated protein CEP250	DEG_APCC_DBOX_1	1720:1728	QRGSLEHMK	APC,CDC20,FZR1	0.8049	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons