DegronMD

Uniprot ID: A7KAX9

Source protein: Rho GTPase-activating protein 32

Source gene: ARHGAP32

Class: LIG_APCC_ABBAyCdc20_2

Location: 42:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8884

ASA_SCORE: 91.3429

COIL: 0.7887

CONS_SCORE: 0.292

DSS_SCORE: 0.4778

HELIX: 0.1724

FCONS_SCORE: 1.0319

RIG_SCORE: 0.6224

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V45A	TCGA-AA-3815	COAD	TCGA	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.6936
p.V45A	DO9924	COAD	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.6936
p.E35K	DO50659	ORCA	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G38S	DO219331	PRAD	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V39A	DO51269	SKCM	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.P41Q	DO38171	SKCM	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P41L	DO47767	STAD	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G57D	DO38328	STAD	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V36L	DO42033	UCEC	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P37L	DO41871	UCEC	ICGC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.H57R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Y57C	ACH-000786	Lymphoma	CCLE	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Y57C	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	KSSVHSE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	LIG_APCC_ABBAyCdc20_2	42:48	KSSVHSE	APC,CDC20,FZR1	0.8884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons