DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: LIG_APCC_ABBAyCdc20_2

Location: 1317:1323

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6421

ASA_SCORE: 62.2714

COIL: 0.2549

CONS_SCORE: 0.312

DSS_SCORE: 0.3146

HELIX: 0.0134

FCONS_SCORE: 0.7792

RIG_SCORE: 0.8762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1312S	TCGA-44-3918	LUAD	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.T1312S	DO23732	LUAD	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1314C	TCGA-66-2785	LUSC	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.S1314C	DO26520	LUSC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.L1320F	TCGA-AJ-A3EL	UCEC	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6981
p.L1320F	DO41542	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6981
p.R1329I	TCGA-D1-A103	UCEC	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R1329I	DO42312	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R1329K	TCGA-FI-A2D5	UCEC	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R1329K	DO41331	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1323E	TCGA-G2-A2EF	BLCA	TCGA	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D1323E	DO726	BLCA	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.5647
p.T1319K	DO228092	EOPC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6195
p.G1331A	DO233262	GACA	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1310Y	DO13863	GBM	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1310Y	DO219146	LUSC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D1310Y	DO41211	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1312E	DO11854	GBM	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F1320L	DO219026	HNSC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F1320L	DO41524	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6981
p.G1312V	DO26469	LUSC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328I	DO27879	ORCA	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G1312R	DO48766	SKCM	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1315P	DO47769	STAD	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1307Y	DO41572	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K1309E	DO42568	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1318D	DO42568	UCEC	ICGC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.6758
p.G1331C	SIDM01119	Other Solid Cancers	GDSC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1331C	ACH-000775	Lung Cancer	CCLE	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1331C	NCI-H727	lung	COSMIC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1111
p.M1328T	SIDM00247	Gastric Carcinoma	GDSC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328T	SIDM01019	Acute Myeloid Leukemia	GDSC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328T	ACH-000356	Gastric Cancer	CCLE	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328T	ACH-002258	Leukemia	CCLE	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328T	MKN45	stomach	COSMIC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1328T	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D1307H	HT-1376	urinary_tract	COSMIC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D1308Y	HT-1376	urinary_tract	COSMIC	KSTLFVD	LIG_APCC_ABBAyCdc20_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KSTLFVD

Degron related mutations and impact score

Drug responses associated with FAT4 mutations

All proteins holding degron of KSTLFVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V0I7	Protocadherin Fat 4	LIG_APCC_ABBAyCdc20_2	1317:1323	KSTLFVD	APC,CDC20,FZR1	0.6421	More...