DegronMD

Uniprot ID: Q9NS73

Source protein: MAP3K12-binding inhibitory protein 1

Source gene: MBIP

Class: LIG_APCC_ABBAyCdc20_2

Location: 140:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5045

ASA_SCORE: 80.2143

COIL: 0.6354

CONS_SCORE: 0.2934

DSS_SCORE: 0.3789

HELIX: 0.2333

FCONS_SCORE: 0.6122

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V138E	DO234398	ESAD	ICGC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H130N	DO229027	LICA	ICGC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.V150A	SIDM00591	Oral Cavity Carcinoma	GDSC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V150A	ACH-002045	Head and Neck Cancer	CCLE	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V150A	HO-1-u-1	upper_aerodigestive_tract	COSMIC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K140N	ACH-000383	Esophageal Cancer	CCLE	KTQIHFD	LIG_APCC_ABBAyCdc20_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS73	MAP3K12-binding inhibitory protein 1	LIG_APCC_ABBAyCdc20_2	140:146	KTQIHFD	APC,CDC20,FZR1	0.5045	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons