DegronMD - Q9NS73(MBIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P23T	TCGA-06-0241	GBM	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.P23T	DO12460	GBM	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.F34S	TCGA-2W-A8YY	CESC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.6871
p.F34S	DO223732	CESC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.6871
p.V29A	TCGA-A6-5665	COAD	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.5825
p.V29A	DO9756	COAD	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.5825
p.N16S	TCGA-DI-A1BU	UCEC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556
p.N16S	DO42023	UCEC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556
p.S36A	TCGA-DJ-A3UN	THCA	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.S36A	DO39252	THCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.V41I	TCGA-EO-A22U	UCEC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.V41I	DO43755	UCEC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.L37I	TCGA-ER-A2NH	SKCM	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.L37I	DO47683	SKCM	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.25
p.E32K	TCGA-FD-A3SQ	BLCA	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.591
p.E32K	DO462	BLCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.591
p.R22S	DO48452	BLCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R22S	DO229010	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R22S	DO229013	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R22S	DO229016	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R22S	DO229003	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.R22S	DO229005	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.V138E	DO234398	ESAD	ICGC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation rewiring degron network	0.2778
p.H130N	DO229027	LICA	ICGC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation rewiring degron network	0.0556
p.H38Q	DO229038	LICA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2222
p.L44I	DO229008	LICA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556
p.L30F	DO33091	PACA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.6981
p.V150A	SIDM00591	Oral Cavity Carcinoma	GDSC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation rewiring degron network	0.2222
p.V150A	ACH-002045	Head and Neck Cancer	CCLE	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation rewiring degron network	0.2222
p.V150A	HO-1-u-1	upper aerodigestive tract	COSMIC	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation rewiring degron network	0.2222
p.K140N	ACH-000383	Esophageal Cancer	CCLE	KTQIHFD	LIG_APCC_ABBAyCdc20_2	140:146	Mutation altering degron motif	0.6918

Kaplan plot for MBIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBIP

UniProt ID: Q9NS73

Entrez ID: 51562

Protein name: MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBIP in