DegronMD

Uniprot ID: Q9NS73

Source protein: MAP3K12-binding inhibitory protein 1

Source gene: MBIP

Class: DEG_APCC_DBOX_1

Location: 26:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6261

ASA_SCORE: 49

COIL: 0.0993

CONS_SCORE: 0.4101

DSS_SCORE: 0.1041

HELIX: 0.8959

FCONS_SCORE: 1.1946

RIG_SCORE: 0.8646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P23T	TCGA-06-0241	GBM	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.25
p.P23T	DO12460	GBM	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.25
p.F34S	TCGA-2W-A8YY	CESC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.6871
p.F34S	DO223732	CESC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.6871
p.V29A	TCGA-A6-5665	COAD	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.5825
p.V29A	DO9756	COAD	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.5825
p.N16S	TCGA-DI-A1BU	UCEC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.0556
p.N16S	DO42023	UCEC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.0556
p.S36A	TCGA-DJ-A3UN	THCA	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.2778
p.S36A	DO39252	THCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2778
p.V41I	TCGA-EO-A22U	UCEC	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.1389
p.V41I	DO43755	UCEC	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.1389
p.L37I	TCGA-ER-A2NH	SKCM	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.25
p.L37I	DO47683	SKCM	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.25
p.E32K	TCGA-FD-A3SQ	BLCA	TCGA	SREVLYEIF	DEG_APCC_DBOX_1	0.591
p.E32K	DO462	BLCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.591
p.R22S	DO48452	BLCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.R22S	DO229010	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.R22S	DO229013	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.R22S	DO229016	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.R22S	DO229003	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.R22S	DO229005	COCA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.H38Q	DO229038	LICA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.2222
p.L44I	DO229008	LICA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.0556
p.L30F	DO33091	PACA	ICGC	SREVLYEIF	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS73	MAP3K12-binding inhibitory protein 1	DEG_APCC_DBOX_1	26:34	SREVLYEIF	APC,CDC20,FZR1	0.6261	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons