DegronMD

Uniprot ID: Q92913

Source protein: Fibroblast growth factor 13

Source gene: FGF13

Class: LIG_APCC_ABBAyCdc20_2

Location: 200:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5618

ASA_SCORE: 97.9143

COIL: 0.7231

CONS_SCORE: 0.5552

DSS_SCORE: 0.3963

HELIX: 0.2416

FCONS_SCORE: 0.91

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K215M	TCGA-55-8203	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M213L	TCGA-91-6836	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A202S	TCGA-95-7039	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A202S	TCGA-A5-A0G1	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A202S	TCGA-A6-5665	COAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6477
p.G192C	TCGA-AP-A0LM	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A201V	TCGA-B7-5816	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6936
p.F204V	TCGA-D1-A16X	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.7068
p.K196T	TCGA-D7-A4Z0	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P208L	TCGA-EE-A2GD	SKCM	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.7222
p.P208S	TCGA-EE-A2GD	SKCM	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.7222
p.N198D	TCGA-EI-6884	READ	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K207T	TCGA-VQ-A8E7	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K197T	TCGA-VQ-A8PK	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.3611
p.A192S	DO9756	COAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A192S	DO23907	LUAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A192S	DO42472	UCEC	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T213M	DO52478	COCA	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A202T	DO231138	LAML	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6028
p.K205M	DO218928	LUAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.6951
p.P190S	DO228855	MALY	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D211N	ACH-000766	Lung Cancer	CCLE	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D211N	NCI-H1648	lung	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G216V	OV-7	ovary	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D192N	NCI-H1648	lung	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92913	Fibroblast growth factor 13	LIG_APCC_ABBAyCdc20_2	200:206	KVAMYKE	APC,CDC20,FZR1	0.5618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KVAMYKE

Degron related mutations and impact score

Drug responses associated with FGF13 mutations

All proteins holding degron of KVAMYKE