DegronMD - Q92913(FGF13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K215M	TCGA-55-8203	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.K215M	TCGA-55-8203	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0833
p.M213L	TCGA-91-6836	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1389
p.M213L	TCGA-91-6836	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1389
p.A202S	TCGA-95-7039	LUAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6477
p.A202S	TCGA-95-7039	LUAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6477
p.A202S	TCGA-A5-A0G1	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6477
p.A202S	TCGA-A5-A0G1	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6477
p.A202S	TCGA-A6-5665	COAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6477
p.A202S	TCGA-A6-5665	COAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6477
p.G192C	TCGA-AP-A0LM	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.G192C	TCGA-AP-A0LM	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1111
p.A201V	TCGA-B7-5816	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6936
p.A201V	TCGA-B7-5816	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6936
p.F204V	TCGA-D1-A16X	UCEC	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.7068
p.F204V	TCGA-D1-A16X	UCEC	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.7068
p.K196T	TCGA-D7-A4Z0	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.K196T	TCGA-D7-A4Z0	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.2222
p.P208L	TCGA-EE-A2GD	SKCM	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation blocking phosphorylation signal	0.7222
p.P208L	TCGA-EE-A2GD	SKCM	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation blocking phosphorylation signal	0.7222
p.P208S	TCGA-EE-A2GD	SKCM	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation blocking phosphorylation signal	0.7222
p.P208S	TCGA-EE-A2GD	SKCM	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation blocking phosphorylation signal	0.7222
p.N198D	TCGA-EI-6884	READ	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.25
p.N198D	TCGA-EI-6884	READ	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.2778
p.K207T	TCGA-VQ-A8E7	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.3056
p.K207T	TCGA-VQ-A8E7	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.3056
p.K197T	TCGA-VQ-A8PK	STAD	TCGA	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation substituting flanking lysine	0.3333
p.K197T	TCGA-VQ-A8PK	STAD	TCGA	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation substituting flanking lysine	0.3611
p.A192S	DO9756	COAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.A192S	DO9756	COAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1111
p.A192S	DO23907	LUAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.A192S	DO23907	LUAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1111
p.A192S	DO42472	UCEC	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.A192S	DO42472	UCEC	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1111
p.T213M	DO52478	COCA	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1389
p.T213M	DO52478	COCA	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1389
p.A202T	DO231138	LAML	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6028
p.A202T	DO231138	LAML	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6028
p.K205M	DO218928	LUAD	ICGC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation altering degron motif	0.6951
p.K205M	DO218928	LUAD	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6951
p.P190S	DO228855	MALY	ICGC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0556
p.D211N	ACH-000766	Lung Cancer	CCLE	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.D211N	ACH-000766	Lung Cancer	CCLE	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1944
p.D211N	NCI-H1648	lung	COSMIC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.1944
p.D211N	NCI-H1648	lung	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1944
p.G216V	OV-7	ovary	COSMIC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0556
p.G216V	OV-7	ovary	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0556
p.D192N	NCI-H1648	lung	COSMIC	VAMYKE	LIG_APCC_ABBA_1	201:206	Mutation rewiring degron network	0.0833
p.D192N	NCI-H1648	lung	COSMIC	KVAMYKE	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1111

Kaplan plot for FGF13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGF13

UniProt ID: Q92913

Entrez ID: 2258

Protein name: Fibroblast growth factor 13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGF13 in